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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia
PARTOMUAN SIMANJUNTAK
LEMBAGA ILMU PENGETAHUAN INDONESIA
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Isolasi Senyawa Aktif dari Ekstrak Hipokotil Sarang Semut (Myrmecodia pendens Merr. & Perry) sebagai Penghambat Xantinoksidase PARTOMUAN SIMANJUNTAK; FANNY FANNY; MUHAMMAD AHKAM SUBROTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Medicinal plant called “sarang semut”, Myrmecodia pendens Merr. & Perry (Rubiaceae), is an epiphyt plant traditionally used in Papua for healing various diseases such as hyperuricemia, rheumatic, and cancer. A chemical compound recognized as xanthinoxidase inhibitor has been isolated from n-buthanol fraction of the plant extract. The isolation was carried out by column chromatography (SiO2, CHCI3-MeOH = 5:1-1:1) and the purification Was conducted using high pressure liquid chromatography (RP, C-18; MeOH-water = 5 : 1). The activity test for Xanthinoxidase inhibitor Was performmed by using modilied Noro method. The pure compound showed xanthinoxidase inhibitor activity of IC50 at 79,77%.
Identifikasi Senyawa Kimia dalam Buah Mahkota Dewa (Phaleria macrocarpa), Thymelaceae PARTOMUAN SIMANJUNTAK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Consecutive extraction of Indonesian medicinal plant, fruit of mahkota dewa, Phaleria macrocarpa (Thymelaceae), by n-hexane, aethylacetate, methanol and then Water afforded fatty acids, steroids, benzophenone and carbohydrate. Elucidation of the chemical structure of the isolated compounds was based upon the spectroscopic spectra such as ultra violet, infrared, and nuclear magnetic resonance (proton and carbon).
Aktivitas Antioksidan Ekstrak Tunggal dan Kombinasinya dari Tanaman Curcuma spp. FAUZY RACHMAN; EMELIA DEVI LOGAWA; HARUMI HERGATIKA; PARTOMUAN SIMANJUNTAK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The aim of this research is to investigate the antioxidant activity of the simple extract and its combination from the rhizome of temulawak (Curcuma xanthorriza), temu giring (Curcuma heyneana), temu ireng (Curcuma aeruginosa), and kunyit (Curcuma Zonga) using the free radical scavenging effect methode namely DPPH (1,1-difenil-2-pikrilhidrazil). The use of combination extract is to explore, wether the antioxidant activity are sinergistic or antagonistic. The rhizomes of each plants were extracted With methanol, then partionated to n-hexane. The result indicated that the single methanol extract of kunyit(Curcuma Ionga) at 100 ppm showed the biggest activity (90.04%), While the combination extract of temulawak (Curcuma xanthorriza) and kunyit (Curcuma Zonga) performed the biggest scavenging activity (98.75%) by ratio 1:1.
Efek Sinergis dari Kombinasi Ekstrak Herba Pegagan (Centella asiatica) dan Ekstrak Daun Kelor (Moringa oleifera) dalam Meningkatkan Fungsi Memori Marcus Laurentius Yudhi Purwoko; Syamsudin Syamsudin; Partomuan Simanjuntak
Jurnal Sains Farmasi & Klinis Vol 9, No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (741.315 KB) | DOI: 10.25077/jsfk.9.2.111-120.2022

Abstract

Otak merupakan pusat syaraf yang sangat berpengaruh terhadap respon anak untuk melihat, mendengar, berpikir, dan melakukan gerakan. Terganggunya fungsi kognitif mengakibatkan terhambatnya perkembangan pertumbuhan dan mempengaruhi kualitas masa depannya khususnya kecerdasannya. Tujuan penelitian ini adalah untuk mengetahui konsentrasi terbaik dari kombinasi ekstrak herba pegagan (Centella asiatica) dan ekstrak daun kelor (Moringa oleifera) dalam meningkatkan fungsi memori dan pembelajaran. Metode yang dilakukan adalah Radial 8-arm maze test yang digunakan untuk mengetahui adanya brain disorder yang berupa defisit pada pembelajaran dan memori serta menggunakan Passive avoidance test untuk mengetahui memori dan fungsi kognitif otak. Histopatologi otak diperiksa dengan menghitung jumlah sel neuron pada CA 1, CA 3 dan DG. Hasil pengujian menunjukkan bahwa kombinasi ekstrak herba pegagan dan daun kelor perbandingan 1:1 meningkatkan fungsi memori dan pembelajaran. Hasil histopatologi otak menunjukkan bahwa kombinasi ekstrak aman untuk digunakan
Co-Authors EMELIA DEVI LOGAWA FANNY FANNY Fauzy Rachman HARUMI HERGATIKA Marcus Laurentius Yudhi Purwoko MUHAMMAD AHKAM SUBROTO Syamsudin Syamsudin