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SRI HARTATI
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Isolasi dan Identifikasi Senyawa Bioaktif Ekstrak Aseton Daun Garcinia lateriflora Blume SRI HARTATI; DEDE RAHMAWATI; SUJASWADI WIRYOWIDAGDO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Preliminary studies have been carried out phytochemical test acetone leaf extract Garcinialateriflora Blume., and toxicity test against shrimp larvae (Artemia salina Leach) and murine cell lineP388. Isolates which showed the highest mortality are proceeded further for fractionation, isolation andpurification. The structure identification of active campound carriedout by analyzing the spectrum of IR ,GC-MS (Gas chromatography mass spectrometer) and proton nuclear magnetic resonance spectrometer(1H-NMR ) and (13C-NMR ). The results showed that the most active against the larval shrimp Artemiasalina L. with LC50 value of 18.03 ug/mL is b-asaron, IC50 of test results on cell line murine P-388 is 47.0ug/mL. This compound was isolated first time from the plant Garcinia lateriflora BL.
Aktivitas Anti Agregasi Platelet dan Aktivitas Antitrombosis Ekstrak Etanol Daun Cinco (Cyclea barbata Miers.) MARISSA ANGELINA; SRI HARTATI; INDAH DEWI; LIA MEILAWATI; IMACULATA IWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The research about anti aggregation platelet and antithrornbotic activity of ethanol extract of Cinco (Cyclea barbata Miers.) (Cb) leaves in mice has been conducted. The background of the research has been reported in vitro anti aggregation platelet and antithrombotic activity of Cb extract. The purpose of this research to know the effect of Cb extract in anti aggregation platelet, antithrombotic activity, prolonged the tail bleeding and coagulation time. The results of the present study indicate that the extract of Cb leaves significantly inhibit platelet aggregation in mice, prolonged tail bleeding time, coagulation time in mice, and thrombotic forming (acute). All of the above measurement have been analyzed significantly using One Way ANOVA programme. Cyclea barbata Miers. significantly prevented death due to thrombus protection whereas as in dose dependent manner. Cyclea barbata Miers. showed significant prolongation of the mice tail bleeding time compared to the control in low dose (150 mg/kg BW). Cyclea barbata Miers. significantly prolonged coagulation time compared to the control in dose dependent manner. The experiment on in vivo anti platelet aggregation showed that Cb (150 mg/kg BW and 300 mg/kg BW) could significantly inhibit aggregation which induced by ADP compared with control. The conclusion of this research is that the extract of Cb leaves has an anti aggregation platelet activity and antithrombotic activity in dose 150. mg/kg BW and 300 rug/kg BW.
Identifikasi Senyawa dari Ekstrak Air Rimpang Bangle (Zingiber cassumunar Roxb.) SRI HARTATI; MEGAWATI MEGAWATI; NINA ARTANTI; MEILYAWATI L.; M. HANAFI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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In a preliminary study on search of marker compounds from raw material phytopharmaceutical water extracts of medicinal herbs bangle (Zingiber casumunar Roxb.) three compounds, namely (E)-4-(3’,4’-dimethoxyphenyl)but-3-en-1-yl acetate (1), (E)-4(3’,4’-dimethoxyphenyl) but-3-en-1-1-ol (2) and 2-Methoxy-8-(3,4-dimethoxyphenyl)-1,4-napthoquinone (3) had been found. The isolation was done by partition and combination of chromatography techniques. The isolated pure compound was analyzed by spectroscopy methods of NMR proton and carbon one and two-dimensional, LC-MS and IR-spectrophotometry IR
Co-Authors DEDE RAHMAWATI IMACULATA IWO INDAH DEWI LIA MEILAWATI M. HANAFI MARISSA ANGELINA MEGAWATI MEGAWATI MEILYAWATI L. NINA ARTANTI SUJASWADI WIRYOWIDAGDO