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Akhmad Darmawan
Research Center for Chemistry, Indonesian Institute of Sciences(LIPI), Serpong
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Isolasi dan Identifi kasi Senyawa Fenolik dari Daun Macaranga hispida Blume Mull.Arg Megawati Megawati; Sofa Fajriah; Galuh Widyawati; Akhmad Darmawan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.722

Abstract

Continuation of research on Macaranga plant has been conducted. In this study, the totalphenol content (TPC) of Macaranga hispida Blume Mull. Arg leaves extracts were investigated. Gallicacid (1) and methyl gallate (2) have been isolated from the ethyl acetate fraction which highest phenoliccontent (8.41 mg GAE/g). Serial techniques of chromatographic and spectroscopic methods, namelyextraction, fractionation, purifi cation, FTIR, LCMS, and FT-NMR were used to isolate and identify theisolates. Cytotoxicity of compound 1 and 2 against P-388 cell line showed that compound 2 has higheranticancer activity compared to compound 1 with IC50 value of 75.53 μg/mL.
Co-Authors Galuh Widyawati Megawati Megawati Sofa Fajriah