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All Journal Jurnal Ilmu Kefarmasian Indonesia
Rahmaniar Rahmaniar
UNIVERSITAS PANCASILA
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Identifi kasi Senyawa β-Sitosterol dari Ekstrak n-heksan Daun Mimba (Azadirachta indica A. Juss) dan Uji Penghambatan Enzim α-Glukosidase Ivan Santoso; Partomuan Simanjuntak; Rahmaniar Rahmaniar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1875.468 KB) | DOI: 10.35814/jifi.v15i2.523

Abstract

Mimba, Azadirachta indica is one of the family Meliaceae plants, which be used to lower blood sugar and contain terpenoids, fl avonoids, alkaloids, saponins, tannins, fatty acids, steroids and triterpenoids. The aim of this research is to isolate and identify one of chemical structure and to know the inhibition α-glucosidase enzyme from extract of leaves Mimba, Azadirachta indica. Extraction is done by maceration using n-hexane, ethyl acetate, methanol, water and then treatment for antidiabetic activity using the inhibition of the enzyme α-glucosidase. Purifi cation of n-hexane extract (the higher activity) is subjected by column chromatography (SiO2; (i).n-hexane-ethyl acetate = 10 : 1 ~ 1 : 1, ethyl acetate, (ii). n-hexane-ethyl acetate = 5 : 1) gave one pure compound as white powder. Identifi cation by interpretation of spectra [UV, IR and NMR (1H, 13C-NMR and DEPT)] the isolate compound is β-sitosterol has inhibion α-glucosidation enzyme as (IC50 208,1 μg/mL).
Co-Authors Ivan Santoso Simanjuntak, Partomuan