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All Journal Majalah Kedokteran Andalas
Dede Agustian Rahman
Department Of Medical Education, Universitas Negeri Padang, Padang, West Sumatra, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Variasi Genetik Region Binding Motif (RBM) Gen Spike SARS CoV-2 Pada Isolat Lokal Sumatera Barat Dede Agustian Rahman
Majalah Kedokteran Andalas Vol 44, No 5 (2021): Online Oktober 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i5.p325-334.2021

Abstract

Tujuan: untuk mengetahui sebaran titik mutasi pada sekuens Region Binding Motif (RBM) gen Spike SARS CoV-2 yang berasal dari isolat lokal Sumatera Barat. Metode: studi deskriptif eksploratif menggunakan koleksi spesimen laboratorium Pusat Diagnostik dan Riset Penyakit Infeksi (PDRPI) Fakultas Kedokteran Universitas Andalas yang diisolasi, dilanjutkan tahap sequencing dan analisa data secara bioinformatika. Hasil: terdapat tiga titik mutasi non-synonimous disepanjang RBM gen Spike SARS Co-2. Kesimpulan: mutasi Asn439Lys merupakan titik mutasi tersering pada RBM gen Spike sebesar 11% diikuti Ser477Gly dan Thr478Ile masing-masingnya 3% dan 1%.
Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat Dede Rahman Agustian; Andani Eka Putra; Dessy Arisanty
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1724-1733.2024

Abstract

Objective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: RNA samples were taken from 98 confirmed COVID-19 cases across various area in West Sumatra. Genetic amplification and next-generation sequencing (NGS) were performed to identify the presence of the Asp614Gly mutation. The frequency of mutations was analyzed using bioinformatics software. Results: Out of the 98 samples analyzed, approximately 97% exhibited the Asp614Gly mutation. The geographic distribution of this mutation showed significant variation among the districts of West Sumatra, with the highest prevalence in urban areas. Conclusion: These findings indicate that the Asp614Gly mutation is highly prevalent in West Sumatra. Associated with increased virus transmissibility, this mutation dominates the circulating virus strains in the region, highlighting the need for ongoing genetic surveillance to guide public health interventions and vaccination strategies.
Co-Authors Andani Eka Putra Dessy Arisanty