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All Journal JKPK (Jurnal Kimia dan Pendidikan Kimia) Kartika : Jurnal Ilmiah Farmasi Pharmacon: Jurnal Farmasi Indonesia
Hanidya Fidela Ulayya
Pharmacy Study Program, Faculty of Pharmacy, Muhammadiyah Surakarta University Jl. Ahmad Yani, Pabelan, Kartasura, Surakarta, Central Java, 57162
Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Study of Virtual Molecular Docking of Avocados Compounds against Pseudomonas aeruginosa (5N5H) by Carbapenemase using DOCK 6 Algorithm Hanidya Fidela Ulayya; Arifa Nursayyida; Fabiola Irianty Atmaja; Broto Santoso
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 6, No 2 (2021): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v6i2.54025

Abstract

Antimicrobial resistance from bacteria is a global health problem that can cause death, and the cause is the emergence of carbapenem resistance Pseudomonas aeruginosa through VIM (Verona integron-encode metallo-β-lactamase), which causes the carbapenem class of antibiotics not to work properly. This species is a gram-negative bacteria which is the main cause of nosocomial pneumonia infection. This study aims to determine in silico inhibitory activity of 50 compounds obtained from avocado (Persea Americana Mill) on VIM, preventing carbapenem antibiotic resistance. The molecular docking process was carried out to test carbapenem's antibiotic resistance control activity by 50 compounds. Docking using DOCK 6 software with a flexible and rigid method, Molecular docking on a protein with PDB ID 5N5H, The target protein was prepared using the Chimera application. Visualization of ligand-protein interactions was carried out with PyMOL and PLIP. The results of the native ligand grid score obtained by each method are -63.013 kcal/mol (Flexible) and -64.032 kcal/mol (Rigid). The best test ligands in the flexible method are 44257090, 14282775 and 44257819, and the grid score are -77.474, -75.274 and -73.219 kcal/mol. The best test ligands in the rigid method are 5280637, 14282775 and 5490064; the grid score is -62.191, -61.714, and -60.453 kcal/mol. The results of the test ligands can provide a better grid score than native ligands, namely in the flexible method. However, the rigid method of grid score results is no better than the native ligand. A good result is that the test ligand grid score is smaller than native ligands, so it has less energy to bind to the active site.
Pemanfaatan Lendir Bekicot Afrika (Achatina fulica) sebagai Obat Luka Bakar Berbasis Nanoemulsi Hanidya Fidela Ulayya; Yuniar Ayu Limantini Suwele; Erika Indah Junior; Nisia Anindita Rinjani; Syarifat izat; Suprapto Suprapto
Kartika : Jurnal Ilmiah Farmasi Vol 6 No 2 (2018)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v6i2.159

Abstract

Abstrak Indonesia merupakan negara tropis yang ditemukan banyak spesies bekicot, salah satunya adalah Achatina fulica (siput tanah). Keberadaan A. fulica kurang dimanfaatkan dan lendirnya dapat dimanfaatkan untuk  mempercepat pengeringan dan penutupan luka. Penelitian sebelumnya menunjukkan bahwa lendir bekicot mengandung acharan sulfat yaitu glycosaminoglycan yang pada fase proliferasi akan membentuk komplek yang berperan penting pada penyembuhan luka. Penelitian ini dilakukan untuk mengetahui cara mengolah mucus Achatina fulica menjadi sediaan nanoemulsi sebagai obat luka bakar dan menguji efek menyembuhkan luka bakar. Sediaan nanoemulsi dari mucus A. fulica adalah sistem w/o (air dalam minyak) dengan fase air adalah gliserol, fase minyak adalah kitosan, dan emulgator adalah Tween 80 dan Span 80. Hasil evaluasi sediaan nanopartikel yang mengandung lender A. fulica menunjukkan distribusi partikel yang baik dan nilai Dispersion Medium Viscosity (Distribusi partikel) didapati hasil sebesar 0,9 mPa.s. Hal ini menunjukkan sediaan nanoemulsi yang diperoleh menunjukkan stabilitas yang baik. Kata kunci:   nanoemulsi, Achatina fulica, luka bakar Utilitazion of  African snail mucus (Achatina fulica) as nanoemulsion for wound burn  Abstract Indonesia is a tropical country that is found in many snail species, one of which is Achatina fulica (land snail). The existence of A. fulica is underutilized and the mucus can be used to speed up drying and wound closure. Previous research shows that snail mucus contains acharan sulfate, namely glycosaminoglycan, which in the proliferation phase will form a complex that plays an important role in wound healing. This study was conducted to find out how to process Achatina fulica mucus into nanoemulsion as a burn medicine and test the effect of curing burns. Nanoemulsion from mucus A. fulica is a system of w/o (water in oil) with water phase is glycerol, oil phase is chitosan, and emulgator is Tween 80 and Span 80. The evaluation of nanoparticles containing lender A. fulica shows particle distribution which is good and the value of Medium Viscosity Dispersion (Particle distribution) is found to be 0.9 mPa.s. This shows that the nanoemulsion obtained showed good stability. Keywords: nanoemulsion, Achatina fulica, burns
Literature Review: Formulation and Characterization of Nanoemulgel for Anticellulite Treatment Ulayya, Hanidya Fidela; Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7157

Abstract

Cellulite, a skin condition characterized by a dimpled, orange-peel appearance, commonly affects the thighs, abdomen, hips, and buttocks. Nanoemulgel, a combined system of nanoemulsion and gel, has gained attention as an effective topical drug delivery system, particularly for lipophilic drugs. This review examines the potential of nanoemulgel formulations in treating cellulite, focusing on their physical characteristics, drug delivery efficiency evaluated through skin penetration and anti-cellulite effects, specifically their ability to inhibit adipogenesis and reduce triglycerides. A total of 5 articles were selected for further review as they met the eligibility criteria, including nanoemulgel formulations containing active ingredients with potential anti-cellulite properties and in vitro or in vivo testing for anti-cellulite effectiveness. The results show that nanoemulgel formulations could be a new way to deliver lipophilic drugs to specific areas of the skin for treating cellulite.
Co-Authors Arifa Nursayyida Broto Santoso Erika Indah Junior Erindyah Retno Wikantyasning Fabiola Irianty Atmaja Nisia Anindita Rinjani Suprapto Suprapto Syarifat izat Yuniar Ayu Limantini Suwele