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All Journal Berkala Ilmiah Kedokteran Duta Wacana Advances In Social Humanities Research
Leonardo Cahyo Nugroho
Duta Wacana Christian University
Humanities Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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SELUK - BELUK HIPERLIPIDEMIA PENINGKATAN PARTISIPASI DAN KOMPETENSI FARMASIS DALAM PENCEGAHAN PENYAKIT KARDIOVASKULAR Leonardo Cahyo Nugroho
Berkala Ilmiah Kedokteran Duta Wacana Vol 3, No 1 (2018): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v3i1.111

Abstract

Hiperlidipidemia atau yang dikenal juga dengan dislipidemia merupakan keadaan terjadinya peningkatan kolesterol plasma, low-density lipoprotein (LDL), trigliserida dan penurunan kadar high-density lipoprotein (HDL) atau kombinasi dari beberapa abnormalitas tersebut. Hiperlipidemia seperti yang telah diteliti merupakan salah satu faktor risiko yang berperan dalam patogenesis penyakit kardiovaskular. Penyakit yang berkaitan dengan kardiovaskular merupakan merupakan penyebab kematian terutama di dunia. Data di Indonesia berdasarkan laporan RISKESDAS bidang biomedis tahun 2007 menunjukkan prevalensi hiperlipidemia atas dasar konsentrasi kolesterol total > 200 mg/dL adalah sebanyak 39,8%. Sedangkan data WHO menunjukkan bahwa peningkatan kadar kolesterol diestimasikan dapat menyebabkan 2,6 juta kematian (4,5% dari total) dan 29,7 juta Disability Adjusted Life Years (DALYS) yaitu sekitar 2% dari total DALYS.
Predicting Mortality and Length of Stay After Laparotomy for Intra-Abdominal Infection: The Role of Physical Examination and Antimicrobial Susceptibility Afif Iman Hidayat; Hansel Austen Budiarto; Pindo Galih Prakoso; Leonardo Cahyo Nugroho
Advances In Social Humanities Research Vol. 4 No. 10 (2026): Advances In Social Humanities Research
Publisher : Sahabat Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/adv.v4i10.703

Abstract

Intra-abdominal infection (IAI) is a surgical emergency associated with high mortality and poor clinical outcomes. This study aimed to analyze the associations of abdominal physical examination findings, vital signs, and antimicrobial susceptibility with clinical outcomes, specifically mortality and length of stay (LOS), in patients undergoing laparotomy for IAI. This retrospective observational cohort study included 60 patients with IAI treated at RSUD Dr. R. Soedjati Soemodiardjo Purwodadi Grobogan between January 2024 and December 2025. Data were extracted from medical records and analyzed using univariate, bivariate, and multivariable analyses, with statistical significance set at p < 0.05. The mortality rate was 26.7%, and the median LOS was 6 days. Bivariate analysis showed that abdominal distension, mean arterial pressure (MAP), heart rate, respiratory rate, body temperature, and oxygen saturation were significantly associated with mortality (p < 0.05). MAP and body temperature were also significantly associated with LOS. Abdominal guarding and extended-spectrum beta-lactamase (ESBL) status were not significantly associated with either clinical outcome. In the multivariable analysis, preoperative length of stay emerged as an independent predictor of prolonged LOS (p < 0.001), whereas no independent predictor of mortality was identified. Physical examination findings, particularly abdominal distension, together with vital signs, were important early clinical parameters associated with mortality and LOS in patients undergoing laparotomy for IAI.
Co-Authors Afif Iman Hidayat Hansel Austen Budiarto Pindo Galih Prakoso