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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Anton H Pudjiadi
Fakultas Kedokteran, Universitas Indonesia
Health Professions Medicine & Pharmacology

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ICAM-1 and S100β plasma value in children with sepsis Lisa Safira; Anton H Pudjiadi; Sukman Tulus Putra
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 14, No 1 (2020): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.139 KB) | DOI: 10.33533/jpm.v14i1.1645

Abstract

ICAM-1 release during sepsis is perceived to be related to brain injury. Whereas S100β  has been known as one of brain injury markers.To measure mean value of ICAM-1, S100β, to find correlation between ICAM-1 and Glasgow Coma Scale (GCS), between S100β and GCS, also ICAM-1 and S100β.Analytical cross sectional study in 34 sepsis children, measurement of ICAM-1 and S100β plasma levels within day 1 and 3 since diagnosis of sepsis.Median level of  ICAM-1 day one 548,1 (158,6 – 1256,1) ng/mL and day three 596,5 (185,5 – 1264,5) ng/mL (p=0,164). S100β median is significantly higher in severe than mild sepsis (p=0,008 dan p=0,021). On third day S100β was negatively related to GCS (r= - 0,452; p=0,003). The correlation observed between ICAM-1 and S100β on day one was r=0,146 (p=0,409) while on third day was r=0,184 (p=0,298).The prevalence of encephalopathy sepsis is 5.9%, Median ICAM-1 is higher on day three. Median of S100β is higher in severe than mild sepsis.There is no correlation between ICAM-1 and GCS in both sepsis. There was negative correlation between S100β  and GCS  on 3rd day of sepsis. No correlation between ICAM-1 and S100β  on both measurement days.
Co-Authors Lisa Safira Sukman Tulus Putra