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All Journal GIZI INDONESIA International Journal of Health, Engineering and Technology
Hana Apsari Pawestri
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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THE OBESE MAN TO OBESE YEAST Hana Apsari Pawestri; Barbora Trubenová
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v33i2.88

Abstract

OBESITAS MOLEKULER PADA MANUSIA, AVERTEBRATA, DAN KHAMIRDalam beberapa tahun terakhir, obesitas telah menjadi salah satu masalah kesehatan utama di negara maju, dengan Amerika Serikat ada di urutan teratas. Meskipun terjadi perbaikan besar pada faktor sanitasi, perawatan kebidanan dan vaksinasi, tetapi usia harapan hidup menurun seiring dengan meningkatnya obesitas. Saat ini, obesitas merupakan epidemi global yang memengaruhi orang dewasa dan anak-anak, dan secara signifikan berhubungan dengan morbiditas dan mortalitas. Epidemi ini disebabkan oleh pergeseran besar penduduk ke pusat-pusat perkotaan, keterlibatan dalam pekerjaan dan aktivitas hidup santai, serta berlimpahnya makanan olahan padat-energi. Gaya hidup modern yang dianut oleh mayoritas penduduk di perkotaan sulit untuk mengurangi obesitas secara signifikan sehingga diperlukan upaya lain seperti terapi secara farmakokinetis dan pemahaman lebih dalam untuk mengendalikan nafsu makan dan asupan makanan. Gaya hidup dan faktor keturunan berperan penting terhadap timbulnya obesitas. Penelitian terhadap mutasi genetika pada manusia dan model organisme memberikan dasar-dasar wawasan tentang proses fisiologis kompleks dalam penguraian metabolisme lemak. Penelitian terbaru dari khamir Saccharomyces cerevisiae, cacing Caenorhabditis elegans, lalat buah Drosophila melanogaster dan ikan zebra Danio rerio menunjukkan bahwa organisme tingkat rendah seperti metazoa memiliki atribut unik yang dapat membantu mengidentifikasi, menyelidiki, bahkan memvalidasi target baru dalam dunia farmasi untuk penyakit-penyakit yang berhubungan dengan metabolisme.Kata kunci: obesitas, keturunan, penyakit metabolik
Epidemiological And Etiological Profile Of Severe Acute Respiratory Infection Syndrome In Indonesia 2025: A Retrospective Descriptive Study Darmawali Handoko; Hana Apsari Pawestri; Yulia Arum Sekarini; Kambang Sariadji; Catharina Yekti Praptiningsih; Subangkit Subangkit; Budiyanto Budiyanto; Arie Ardiansyah Nugraha; Markus Evan Anggia
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.614

Abstract

Severe acute respiratory infection syndrome is a major cause of hospitalization and mortality worldwide and remains a critical public health concern in Indonesia. Laboratory-based syndromic surveillance plays an essential role in monitoring circulating respiratory pathogens and detecting emerging threats. To describe the demographic characteristics and temporal distribution of severe acute respiratory infection syndrome cases identified through laboratory-based syndromic surveillance in Indonesia during 2025. We conducted a retrospective descriptive study using routinely collected laboratory surveillance data from the National Biological Public Health Laboratory, Indonesia, during January-December 2025. The cases were defined according to World Health Organization criteria. Specimens submitted through passive syndromic surveillance were tested using polymerase chain reaction-based assays following national protocols. Descriptive analyses were performed to summarize demographic characteristics, laboratory results, and temporal and geographic distribution of the cases. A total of 194 severe acute respiratory infection syndrome cases were identified in 2025. Children under five years of age accounted for 43.8% of cases, and males represented 59.3%. Most specimens were respiratory (94.3%). Overall, 75.2% of cases tested negative for pathogens included in the testing panel. Among laboratory-confirmed cases, Legionella pneumophila (19.1%) and influenza A (8.2%) were the most frequently detected pathogens, while SARS-CoV-2 was detected in one case (0.5%). Severe acute respiratory infection disease cases were reported throughout the year, with fluctuations in weekly case counts and wide geographic distribution across provinces. Severe acute respiratory infection syndrome occurred year-round in Indonesia during 2025, with young children and older adults disproportionately affected. Despite limitations inherent to passive laboratory-based surveillance, these findings demonstrate the value of integrated severe acute respiratory infection disease surveillance for monitoring severe respiratory infections and informing public health preparedness in tropical settings.
Co-Authors Arie Ardiansyah Nugraha Barbora Trubenová Budiyanto Budiyanto Catharina Yekti Praptiningsih Darmawali Handoko Kambang Sariadji Markus Evan Anggia Subangkit Subangkit Yulia Arum Sekarini