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All Journal Borneo Journal of Pharmacy
Vinotha Sanmugarajah
University of Jaffna
Medicine & Pharmacology

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Pharmacological screening of Eryngium foetidum Linn – A Review Galamula Hewage Tharuka Kanchana Hemachandra; Sinnadurai Thuvaragan; Vinotha Sanmugarajah
Borneo Journal of Pharmacy Vol. 4 No. 4 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i4.2377

Abstract

Eryngium foetidum L. (Family Apiaceae) is a biennial herb, and it is used as a culinary herb and spice across the different countries of the world, including Sri Lanka, India, Bangladesh, Malaysia, Singapore, etc. due to its high aroma quality. Also, it is used to treat several ailments, such as respiratory diseases, gastrointestinal ailments, and skin diseases among different indigenous populations for its medicinal properties. Based on ethnomedical evidence, many studies have been conducted to identify the phytoconstituents, underlying mechanisms, and related pharmacological effects of different parts of this plant. This study reviewed the current state of findings related to the Pharmacological activities of E. foetidum. Based on this review, this plant is widely used for ethnomedical and culinary purposes. Pharmacological screening of the plant revealed that it had different activities such as anti-inflammatory, antioxidant, antimicrobial, anthelminthic, anticonvulsant, anticancer, antidiabetic, antimalarial, larvicidal, and hepatoprotective activities. This review further promised that potential new chemical entities could be elicited from the phytoconstituents of E. foetidum.
Comparative Analysis of Qualitative and Quantitative Phytochemical Evaluation of Selected Leaves of Medicinal Plants in Jaffna, Sri Lanka Gowri Rajkumar; Panambara Arachchilage Harini Rangana Panambara; Vinotha Sanmugarajah
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3091

Abstract

The traditional system of medicine in Sri Lanka has shown much better improvement, has fewer side effects, and is less expensive than modern synthetic drugs in the treatment of many diseases. The objective of the present study was to comparatively evaluate the qualitative and quantitative analysis of phytochemical constituents of leaves of Murraya koenigii (L.) Spreng., Tinospora cordifolia (Wild) Hook.f., Enicostemma axillare (Lam) A. Raynal, and Gymnema sylvestre R. Br. were collected from Jaffna District. The shade-dried leaves were powdered and extracted with ethanol using the cold extraction technique. These ethanolic extracts were subjected to phytochemical analysis using recommended laboratory techniques. The one-way analysis of variance (ANOVA) and Tukey's multiple comparisons at probability value (p <0.05) were used in the statistical analysis of the data. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, terpenoids, steroids, saponins, phenols, and glycosides. Murraya koenigii shows the highest phenol and alkaloid contents (1960.71±66.88 and 19.42±0.26). Enicostemma axillare shows the highest flavonoid and tannin contents (22.27±0.86 and 1.26±0.017). Therefore, E. axillare and M. koenigii can be used as nutraceuticals in traditional medicine.
A Review of Anti-hyperglycemic Effects of Curry Leaf Tree (Murraya koenigii) Vinotha Sanmugarajah; Gowri Rajkumar
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3300

Abstract

Diabetes mellitus is becoming a metabolic disease that is defined by the level of hyperglycemia. Nowadays, it has a serious threat to public healthiness in throughout the world. Constituents and extracts isolated from diverse natural resources, mainly plants, have constantly been a rich store for controlling and treating diabetes problems. Numerous researches are ongoing to identify the suitable traditional medical drugs, medicinal herbs, and resources for managing this condition. Murraya koenigii Spreng (family Rutaceae) is commonly known as a ‘curry leaf tree’ locally. It is widely scattered in India and Sri Lanka, and leaves are commonly used for cooking. And also mainly used for various health conditions such as diabetes, anemia, diarrhea, and others. The present review aimed to critically review the anti-hyperglycemic effect of the M. koenigii based on the review, in vitro, in vivo, and clinical studies. Based on this review, the M. koenigii possess flavonoids, phenols, saponins, alkaloids, tannins, and cardiac glycosides. It has shown a potential anti-hyperglycemic effect on induced diabetic rats. This review reported the potential of M. koenigii and its extract to be a high-value dietary product in terms of its anti-hyperglycemic effects and industrial profits. Therefore, the present review supports the researchers and readers/users to realize the importance of using M. koenigii in managing diabetes mellitus. Further, this review provides a valuable document for future scientific-related clinical trials in diabetic patients.
Co-Authors Galamula Hewage Tharuka Kanchana Hemachandra Gowri Rajkumar Panambara Arachchilage Harini Rangana Panambara Sinnadurai Thuvaragan