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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Farmasi Higea
Rina Wahyuni
STIFARM Padang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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KARAKTERISASI FISIKOKIMIA NANOKRISTAL EKSTRAK HERBA SELEDRI ( Apium graveolens L.) DENGAN PERBEDAAN KONSENTRASI POLOXAMER188 Henni Rosaini; Rina Wahyuni; Boyke Panata Sinaga; Wahyu Margi Sidoretno
JURNAL FARMASI DAN MAKANAN Vol 4 No 1 (2020): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v4i1.1578

Abstract

Celery (Apium graveolens L) is a plant of Apiaceae family which contains flavonoids, saponins, tannins, essential oils, apiin, apigenin, choline, asparagine, vitamin A, B, C. Apigenin contained in celery included in the BCS (Biopharmaceutics Classification System) class II, which has low solubility and high permeability drugs. One method for increasing solubility is the nanocrystal method. Where the purpose of this study was to see the effect of differences in the concentration of poloxamer 188 on the characterization of nanocrystal. The results of the particle size analyzer (PSA) showed particle size distribution in formula 1 the concentration of poloxamer 188 40% 6 hour grinding time of 1648.5 nm with a potential zeta value of -11.2. While the formula 2 concentration of poloxamer 188 50% and formula 3 the concentration of poloxamer 188 60% with a 5 hour grinding time of 1049.6 and 1483.2 with a potential zeta value of -12.5 and -8.9. From the FT-IR analysis shows the presence of clusters in formulas 1, 2, and 3 which are not found in apigenin which is a celery marker compound, on the contrary there are groups on apigenin which are not found in formulas 1, 2, and 3.
Formulasi dan Evaluasi Sediaan Emulgel dari Ekstrak Kulit Buah Naga Merah (Hylocereus lemairei (Hook.) Britton & Rose) dengan Kombinasi Gelling Agent Rina Wahyuni; Henni Rosaini; Indra Makmur; Feni Azwar
Jurnal Farmasi Higea Vol 12, No 1 (2020)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.407 KB) | DOI: 10.52689/higea.v12i1.259

Abstract

Kulit buah naga merah (Hylocereus lemairei (Hook.) Britton & Rose)  diduga mengandung senyawa-senyawa yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Penelitian ini bertujuan untuk memformulasi sediaan emulgel ekstrak etanol kulit buah naga  merah dan bagaimana pengaruh pemberian ekstrak etanol dari kulit buah naga sehingga dapat  menghambat pertumbuhan bakteri Staphylococcus aureus. Ekstrak etanol dibuat dalam 5 formula masing-masing formula mengandung ekstrak etanol sebanyak 1% dan masing-masing formula mengandung kombinasi gelling agent yang berbeda-beda. Klindamysin digunakan sebagai kontrol positif dan CMC 1% digunakan sebagai kontrol negatif. Parameter yang diamati adalah luasnya diameter zona hambat. Data yang diperoleh dianalisis secara dekriptif. Hasil penelitian menunjukkan bahwa ekstrak kulit buah naga merah dapat menghambat pertumbuhan antibakteri sebanyak 6,18 mm hanya pada formula IV dan dikategorikan sedang.
Co-Authors Boyke Panata Sinaga Feni Azwar Indra Makmur Rosaini, Henni Wahyu Margi Sidoretno