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Fuad Adi Prasetyo
Universitas Jember
Nursing

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NEPHROPROTECTIVE EFFECT OF GARLIC CHIVES (ALLIUM TUBEROSUM) ON BUN AND CREATININE LEVELS OF WISTAR RATS INDUCED BY DOXORUBICIN Erfan Efendi; Fuad Adi Prasetyo; Mudzakir Taufiqurrahman; Kiky Martha Ariesaka; Ain Yuanita Insani; Brilliant Givya Ariansari
NurseLine Journal Vol 1 No 2 (2016): November 2016
Publisher : Faculty of Nursing, Universitas Jember

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Abstract

Cancer is the most leading disease that cause of death. Doxorubicin chemotherapy is often used in cancer treatment, because of its effectiveness. Although doxorubicin has a positive effect for killing cancer cell, doxorubicin has many side effects, one of which doxorubicin can cause kidney damage through the process of interstitial fibrosis. Utilization garlic chives extract as co chemotherapy to reduce renal damage induced by doxorubicin is a prospective opportunities. This study aimed to analyze the effect of garlic chives extract as a nephroprotective on levels of BUN and creatinine of wistar rats induced by doxorubicin. The research method was quasi experimental design with post test only randomized controlled group. The results showed that extracts of garlic chives can reduce levels of BUN and creatinine (p <0.05) in the group that only induced by doxorubicin. In conclusion, extract of garlic chives has nephroprotecive effects on wistar rats which were induced by doxorubicin.
Co-Authors Ain Yuanita Insani Brilliant Givya Ariansari Erfan Efendi Kiky Martha Ariesaka Mudzakir Taufiqurrahman