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All Journal AL-ULUM: JURNAL SAINS DAN TEKNOLOGI
Richa Purnamasari
Fakultas Farmasi, Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Energy

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Journal : AL-ULUM: JURNAL SAINS DAN TEKNOLOGI

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PREDIKSI SENYAWA EUCALYPTUS SEBAGAI INHIBITOR POTENSIAL COVID-19 MAIN PROTEASE (Mpro) SECARA MOLECULAR DOCKING Muhammad Fauzi; Fauzi Rahman; Yulistia Budianti Soemari; Richa Purnamasari
AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 6, No 2 (2021)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.702 KB) | DOI: 10.31602/ajst.v6i2.5218

Abstract

The development of cases infected with the COVID-19 virus in Indonesia continues to increase. COVID-19 is a member of the corona virus family that has spread throughout the world. The COVID-19 Main protease is considered a suitable target for drug design against SARS infection because it plays a role in the processing of polyproteins required for the reproduction of the coronavirus. Eucalyptus are claimed to be able to ward off the COVID-19 virus. Therefore it is necessary to evaluate the content of eucalyptus compounds against Main proteases by docking studies. Based on the results of research conducted using the active site on the Main protease, it is known that eucalyptus (-)-globulol, epiglobulol, and ledol compounds have free energies of -7.23 kcal/mol, -7.91 kcal/mol, and -7.39 kcal/mol, respectively. Remdesivir as a therapeutic drug for COVID-19 has a free energy of -7.67 kcal/mol. These three compounds bind to the amino acid Glu166 as remdisivir with the best binding affinity on the active site of the Main protease. So these three compounds have the potential to inhibit the COVID-19 virus.
Co-Authors Fauzi Rahman Muhammad Fauzi Yulistia Budianti Soemari