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All Journal Budapest International Research in Exact Sciences (BirEx Journal)
Florenly Florenly
Departement of Medicine, Faculty of Medicine, University of Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Physics Transportation

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Effectiveness of Turmeric Ethanol Extract (Curcuma Longa) in Accelerating Wound Healing After in Wistar Rats Zhou Guoqing; Florenly Florenly; Liena Liena; Johannes Bastira
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2975

Abstract

RISKESDAS results in 2018 showed the DMFT (Decay, Missing and Filled Teeth) index of Indonesian people nationally 2.5% in 2013, rising to 57.6% in 2018. The main cells involved in the wound healing process are fibroblasts. Fibroblasts are stem cells that play a role in forming and putting fibers in the matrix, especially collagen fibers. Turmeric (Curcuma longa) has several pharmacological properties, including anti-inflammatory, anticancer, antioxidant, antiulcus, and antibacterial actions. The content of flavonoids in Curcuma longa, as an immunostimulating substance, then the production of growth hormones such as EGF, TGFα, PDGF, VEGF, FGF, and TGFβ will also increase, so that wound healing can be accelerated. This study was conducted to find out the effectiveness of turmeric ethanol extract (Curcuma Longa) in accelerating wound healing after tooth extraction. This study used 32 male Wistar rats divided into 2 groups, namely the treatment group given turmeric extract (Curcuma Longa) 45% and the treatment group given turmeric (Curcuma Longa) 90%. The wound healing process was assessed by observing fibroblast tissue on the 5th day after the extraction of Wistar mouse teeth. The results of the Chi-Square Test statistical analysis showed a significant difference in the number of fibroblasts in the wound healing process in Wistar rats after tooth extraction between the treatment group given turmeric extract (Curcuma Longa) 45% and the treatment group given Turmeric extract (Curcuma Longa) 90% after the 5th day with p-value (0.032)<0.05). Turmeric extract (Curcuma longa) is 45% and 90% effective in speeding up the healing time of post-extraction wounds of Wistar mouse teeth. Turmeric extract (Curcuma longa) is 90% more effective than turmeric extract (Curcuma longa) 45% in speeding up wound healing time after extraction of rat teeth Wistar because of the flavonoid content in turmeric extract (Curcuma longa) 90% which helps accelerate wound healing higher than turmeric extract (Curcuma longa) 45%.
Influence of Intrinsic and Extrinsic Motivation on Job Satisfaction of Implementing Nurses at RSU Royal Prima Marelan in 2021 Lin Shikun; Florenly Florenly; Liena Liena; Johannes Bastira
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2976

Abstract

Job satisfaction is an individual's general attitude toward the work he or she does. A person with a high level of job satisfaction shows a positive attitude towards his or her job, while someone dissatisfied with his work shows a negative attitude towards his work. Nurses are the spearhead and have an important position in producing the quality of health services in hospitals because the services they provide are carried out for 24 hours continuously. The purpose of this study was to determine the effect of intrinsic and extrinsic motivation on the job satisfaction of the managing nurse. This type of research is a non-experimental quantitative study with a descriptive approach (cross-sectional survey) and associative analysis, conducted at Royal Prima Marelan Hospital, March 2021. The study population of 377 people, determining the number of samples with the formula SEM (Structural Equation Modelling) was not obtained 100 samples. The sample determination technique used in this study is to use a purposive sampling approach. Bivariate analysis with Chi-Square test, and multivariate with multiple logistic regression with p-value (0.05). The results of the study that simultaneously, the variable Award (X1), Achievement (X2), Supervision (X3), Responsibility (X4), has an influence on the variable of job satisfaction with p-value < 0.05. While the variable Wage (X5), Work Environment (X6), Status (X7), with a p-value of > 0.05, does not affect the variable job satisfaction of the managing nurse at Royal Prima Marelan Hospital. The results of the multivariate analysis, that from independent variables namely Awards, Achievement, Supervision, Responsibility, which allegedly affect job satisfaction the most influential is the variable of responsibility with a p-value of 0.017 < 0.05. Finally, the OR value obtained is 7,516, meaning a high sense of responsibility, which has a 7,516 times chance of affecting the level of job satisfaction of employees at Royal Prima Marelan Hospital.
Effectiveness of Turmeric Ethanol Extract Cream Preparation (Curcuma Longa) in Speeding up Wound Healing in Male Wistar Rats Wang Ling; Florenly Florenly; Liena Liena; Dewi Riastawaty Purba
Budapest International Research in Exact Sciences (BirEx) Journal Vol 4, No 1 (2022): Budapest International Research in Exact Sciences, January
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v4i1.3472

Abstract

Injury is the loss or damage of some body tissues, due to a factor that interferes with the body's protective system. The results of several studies state turmeric rhizome extract is effective in wound healing. This study aims to find out the effect of turmeric extract (Curcuma longa) on wound healing in white rats. This type of research is experimental with the approach of Pre-test and Post-test group only control design, conducted November to December 2020. The samples used were turmeric rhizomes (Curcuma Longa) and male white rats. Determination of the size of the sample according to Federer's formula, so that the number of samples as many as 25 mice, the division of 4 treatment groups and 1 control group. The results of the study from the Anova test obtained a Sig value. Calculate 0.000 while sig value (α) is 0.05 which means sig value. Count sig < (α). This means that there is a real influence of the administration of turmeric extract (Curcuma Longa) on the healing of sores in mice. Turmeric ethanol extract (Curcuma Longa) has several bioactive compounds such as alkaloids, flavonoids, saponins, and tannins that play a role in wound healing. The optimum concentration of turmeric ethanol extract (Curcuma Longa) that can cure sores in white rats is 5%. The highest percentage of cures on k-14 days was in the positive control (Bioplacenton®) which was 95% and followed by extract 5% v/ v with a cure percentage of 90%. The creamy preparation of turmeric ethanol extract (Curcuma Longa) has an ability that is close to Bioplacenton® in healing wounds in mice.
Co-Authors Dewi Riastawaty Johannes Bastira Ginting Liena Liena Lin Shikun Wang Ling Zhou Guoqing