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All Journal The Journal of The Indonesian Medical Students´ Association Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Ariana Setiani
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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The Potency of Probiotic as Adjuvant Therapy on The Treatment of Autistic Spectrum Disoders (ASD) Khoiria Qodriani, Titisari; Setiani, Ariana
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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Abstract

Autistic Spectrum Disorders (ASD) is a neurodevelopment disorder which the case increases continously. Recent studies have proved the linkage between gut dysfunction and central nervous system disorders (gut-brain axis) through immunoexcitotoxic mechanism. The overgrowth of pathogen bacteria such as Clostridia in ASD childrenss intestine produce neurotoxin and induce chronic local inflammation. It stimulates the increasing of proinflammatory cytokines level and activation of microglia which induce neural damage. Moreover, dipeptidyl peptidae IV (DPP IV) deficiency in most ASD children increase exorphine level in the bloodstream which induces the presence of some ASD symptoms. Probiotic is potential in preventing gut-brain axis disorders by inducing immunomodulation and exorphine degradation as well as reducing microglial activation. Therefore, it can be an adjuvant therapy for ASD.Key words: autism, autistic spectrum disorders, probiotic.
Modified Snakes and Ladders to Increase Elementary Students Knowledge About Anticipating Child Sexual Abuse Widyastuti, Yani; Setiani, Ariana; Eka, Yuliasti; Wulandari, Diah
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 2 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i2.9331

Abstract

One in four girls and one in 13 boys globally experience child sexual abuse (CSA), a public health crisis. Snakes and ladders-based reproductive health education to combat CSA. This study examined the impact of snakes and ladders game modification on CSA anticipation knowledge. The study was quasi-experimental with pre- and post-test control groups. Sample size was 118. The experimental group received a modified snakes and ladders game comprising 59 students, whereas the control group received a brochure. The sampling method is sequential. This study included grade 4-6 primary pupils. The snakes and ladders modification group averaged pretest 68.3 SD 16.4 and posttest 82.0 SD 12.5. The leaflet group averaged 67.8 SD 11.4 pre-test and 76.4 SD 14.1 post-test. The snake and ladder modification group increased 13.6 and the leaflet group 8.5. An average difference of 5.1 was found between the snakes and ladders modification group and the leaflet, with a p-value of 0.037 < It can be concluded that snake modification increases female students' average knowledge.
Peran Gut Microbiome pada Attention Deficit Hyperactivity Disorder (ADHD) Setiani, Ariana; Maharatih, Gusti Ayu
Majalah Kedokteran Indonesia Vol 75 No 3 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.3-2025-1096

Abstract

Attention deficit hyperactivity disorder (ADHD) is a behavioral disorder, associated with neurodevelopmental disorders in the form of persistent patterns of inattention or hyperactivity and impulsivity that interfere with childhood functioning and development. The prevalence of ADHD is estimated at 3.4% in children and adolescents worldwide.1 In 60-80% of cases, ADHD symptoms persist into adulthood.2
Co-Authors Diah Wulandari Eka, Yuliasti Maharatih, Gusti Ayu Titisari Khoiria Qodriani Widyastuti, Yani