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All Journal JSFK (Jurnal Sains Farmasi & Klinis)
Netty Marusin
Jurusan Biologi, FMIPA Universitas Andalas
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Efek Proteksi Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr. ) terhadap Aterosklerosis Suhatri Suhatri; Netty Marusin; Delva Yeni; Rahmi Yosmar
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (904.784 KB) | DOI: 10.29208/jsfk.2014.1.1.20

Abstract

A study of the protection effect of ethyl acetate fraction of toona leaves (Toona sureni (Blume) Merr.) to the atherosclerotic blood vessel on the hypercholesterolemic quails has been carried out. The observation was conducted for histopathology of the blood vessel. The hypercholesterolemic quails were obtained through high-fat diet and propylthiouracil (PTU) induction. Aortic wall thickness, changes on the aortic lumen are, and visual endothelial cell dysfunction were determined. The study showed that the ethyl acetate fraction of toona leaves on the dose of 50 mg/kg body weight exhibited the best protection effect, indicated by aortic wall thickness and lumen area, and the degree of endothelial cell dysfunction which were not significantly different with the negative control group (p>0.05), but significantly different with positive control group (p<0.05).
Co-Authors Delva Yeni Rahmi Yosmar Suhatri Suhatri