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All Journal JSFK (Jurnal Sains Farmasi & Klinis)
Riana Zikra Fauzi
Fakultas Farmasi Universitas Andalas
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Dispersi Padat Asam Usnat dengan Teknik Freeze Drying menggunakan Poloxamer 188 sebagai Polimer Deni Noviza; Lili Fitriani; Riana Zikra Fauzi
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (874.228 KB) | DOI: 10.25077/jsfk.5.1.41-48.2018

Abstract

This study aimed to improve the solution of usnic acid, a poorly soluble drug using solid dispersions (SDs). The SDs were prepared by a freeze-drying technique with poloxamer 188 as a polymer. The physicochemical properties of the SDs were characterized using X-ray diffractometry (XRD) and Fourier transform-infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM),. In addition, drug content, solution test and dissolution profile  was evaluated by using usnic acid (pure drug) and physical mixture as a reference. The results from  XRD and SEM showed that usnic acid was molecularly dispersed in the SDs as an amorphous form. The FT-IR results suggested that intermolecular hydrogen bonding had formed between usnic acid and its carriers. The result of solubility test showed that solubility of solid dispersions 1:1; 1:2; 2:1 (5.80 µg/ml; 6.94 µg/ml ; 4.88 µg/ml) were higher than the physical mixture 1:1 ( 0.39 µg/mL) and pure asam usnat have the lowest solubility (0.34 µg/mL). In conclusion, SDs prepared by a freeze-drying technique used poloxamer as a polymer can be used to enhance solubility of usnic acid
Co-Authors Deni Noviza Lili Fitriani