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All Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Unnes Journal of Public Health
Kartika Nugraheni
Universitas Muhammadiyah Semarang
Health Professions Medicine & Pharmacology Public Health Other

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Aktivitas antidislipidemia Tepung tempe dan susu kedelai pada profil lipid tikus diabetes yang diinduksi streptozotocin Kartika Nugraheni; Siti Harnina Bintari
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 4 NOMOR 3, SEPTEMBER 2016
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.533 KB) | DOI: 10.21927/ijnd.2016.4(3).147-153

Abstract

ABSTRACTBackground : dyslipidemia increases risk of cardiovascular disease on diabetes patients. Soybean contain many bioactive compounds which can help control lipid profile.Objectives : analyze the difference between fermented soybean (tempe flour) and unfermented soybean (soymilk) on lipid profile in diabetic rats.Methods : thirty male sprague dawley rats divided into 3 groups (1) diabetic control (2) tempe flour 1,8 gr (3) soymilk 1,35 gr. Tempe flour and soymilk were given for 28 days. Profile lipid measured including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol. The data then were analyzed using Anova with confidence level of 95%.Results : the decrease values of total cholesteril, triglycerides and LDL cholesterol were better in tempe flour group (p<0,05). In addition, tempe flour group also showed better increase in the value of HDL cholesterl (p<0,05)Conclusion :fermented soybean (tempe flour) showed better antidyslipidemic activity than unfermented ones 
A New Opportunity Related Hypercholesterolemic and the Improvement of Glucose Levels, Lipid Profiles, and Microbial Activity: Red Dragon Fruit (Hylocereus polyrhizus) Peel Yogurt and Animal Study Natalia Desy Putriningtyas; Widya Hary Cahyati; Refani Alycia Kusuma; Kartika Nugraheni; Alfiana Ainun Nisa
Unnes Journal of Public Health Vol. 13 No. 2 (2024)
Publisher : Universitas Negeri Semarang (UNNES) in cooperation with the Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ujph.v13i2.4365

Abstract

 Hypercholesterolemia estimated to cause 2.6 million deaths and 29.7 million disability problems.The incidence of Noncommunicable diseases (NCD) such as coronary heart disease (CHD), type2 diabetes, and some types of cancer can be involved with hypercholesterolemiaed. Red dragonfruit (Hylocereus polyrhizus) peel contains total phenolic compounds, flavonoids and dietary fiber.Red dragon fruit (Hylocereus polyrhizus) peel, which was originally considered as trash can beused to produce yogurt. This study aimed to analyse the effect of red dragon fruit (Hylocereuspolyrhizus) peel yogurt on levels of fasting blood glucose, lipid profile and microbial activity inhypercholesterolemic Wistar rats. This was an experimental- research with pre and post-test control group design. A total of 25 male Wistar rats were divided into five groups randomly. Hypercholesterolemic conditions in the Wistar rats were obtained from consuming solution consisted of 1% of cholesterol powder and 0.5% of cholic acid for 14 days. Each Wistar rats received 20 g/day standard feed. The grouping were Group 1 (negative control group); Group 2 (hypercholesterolemic group); Group 3 (1.8 ml/kg b.wt/day of dragon fruit peel yogurt); Group 4 (2.7 ml/kg b.wt/day of dragon fruit peel yogurt); Group 5 (3.6 ml/kg b.wt/day of dragon fruit peel yogurt). The intervention was performed for 28 days. Blood glucose levels and lipid profiles weremeasured before and after the intervention. Blood glucose, lipid profiles and microbial activity weremeasured using GOD-PAP, automatic biochemistry analyser and pour plate method respectively.Data were analysed using paired t test and one-way ANOVA. Blood glucose, TC, LDL-C, TGlevels were decreased, and the other side HDL-C was increased significantly in the Group dragonfruit peel. There was no difference in the total number of microbes in all groups. Dragon fruit peelyogurt is effective in improving glucose levels and lipid profile of hypercholesterolemic Wistar rats. 
Co-Authors Alfiana Ainun Nisa Natalia Desy Putriningtyas, Natalia Desy Refani Alycia Kusuma Siti Harnina Bintari Widya Hary Cahyati