Kartika Nugraheni
Universitas Muhammadiyah Semarang

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Aktivitas antidislipidemia Tepung tempe dan susu kedelai pada profil lipid tikus diabetes yang diinduksi streptozotocin Kartika Nugraheni; Siti Harnina Bintari
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 4 NOMOR 3, SEPTEMBER 2016
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.533 KB) | DOI: 10.21927/ijnd.2016.4(3).147-153

Abstract

ABSTRACTBackground : dyslipidemia increases risk of cardiovascular disease on diabetes patients. Soybean contain many bioactive compounds which can help control lipid profile.Objectives : analyze the difference between fermented soybean (tempe flour) and unfermented soybean (soymilk) on lipid profile in diabetic rats.Methods : thirty male sprague dawley rats divided into 3 groups (1) diabetic control (2) tempe flour 1,8 gr (3) soymilk 1,35 gr. Tempe flour and soymilk were given for 28 days. Profile lipid measured including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol. The data then were analyzed using Anova with confidence level of 95%.Results : the decrease values of total cholesteril, triglycerides and LDL cholesterol were better in tempe flour group (p<0,05). In addition, tempe flour group also showed better increase in the value of HDL cholesterl (p<0,05)Conclusion :fermented soybean (tempe flour) showed better antidyslipidemic activity than unfermented ones 
Effects of Moringa–Mackerel Supplementation on Albumin, IGF-1, and IL-1β in Protein-Restricted Wistar Rats Hana Astrid Elisa Pontoh; Sufiati Bintanah; Luthfia Dewi; Kartika Nugraheni; Toto Sudargo
Journal of Nutrition Explorations Vol. 4 No. 4 (2026): November
Publisher : Politeknik Kesehatan Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/jone.v4i4.794

Abstract

Protein restriction may affect circulating proteins, anabolic regulation, and inflammatory biomarkers. This study evaluated serum albumin, insulin-like growth factor-1 (IGF-1), and interleukin-1β (IL-1β) responses to different formulations of mackerel fish meal (Rastrelliger kanagurta) and moringa leaf powder (Moringa oleifera), collectively referred to as KemoriQ, in male Wistar rats. In a randomized pretest–posttest controlled experiment, 45 rats were allocated to five groups (n = 9): normal control (K+), protein-restricted control (K−), K1 (75% mackerel:25% moringa), K2 (50%:50%), and K3 (25%:75%). A protein-restricted diet was administered for 14 days, followed by 21 days of supplementation. Serum albumin was measured using the bromocresol green method, while IGF-1 and IL-1β were measured using ELISA. Statistical analyses included paired t-tests, one-way ANOVA of change scores, and Tukey’s HSD. Among the supplemented groups, K1 had the highest post-intervention albumin (3.45 ± 0.25 g/dL) and IGF-1 (118.2 ± 7.1 ng/mL) concentrations, whereas K3 had the lowest post-intervention IL-1β concentration (32.1 ± 2.9 pg/mL). The largest reported increases in albumin and IGF-1 occurred in K2 (0.77 ± 0.19 g/dL and 3.39 ± 0.71 ng/mL, respectively), while K3 showed the largest reported decrease in IL-1β (−18.10 ± 0.26 pg/mL). These change scores require verification against the original paired data. Overall, the formulations exhibited different biochemical response patterns; however, nutritional or functional recovery cannot be established from these biomarkers alone.