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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Komunitas
Fauna Herawati
Fakultas Farmasi Universitas Surabaya, Indonesia
Humanities Education Environmental Science Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Efektivitas dan Keamanan Penggunaan Aztreonam pada Pasien dengan Cystic Fibrosis : Sebuah Kajian Sistematik Sahrul Riadi; Fauna Herawati
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.57 KB) | DOI: 10.36418/syntax-literate.v7i5.6961

Abstract

Cystic fibrosis (CF) adalah penyakit resesif autosomal yang ditandai dengan sekresi paru yang kental, infeksi saluran napas kronis dan insufisiensi pankreas. Bakteri patogen utama penyebab CF yaitu Pseudomonas aeruginosa (Pa). Aztreonam merupakan antibiotik yang digunakan sebagai terapi pasien CF. Tujuan dari kajian sistematik ini adalah untuk mengetahui efektivitas dan keamanan dari aztreonam pada pasien CF dalam perbaikan fungsi paru. Fungsi paru dinilai dengan mengukur nilai forced expiratory volume in one second (FEV1) pada pasien setelah diberikan intervensi. Perbaikan fungsi paru juga dapat diukur melalui kuesioner cystic fibrosis-yang direvisi (CFQ-R)-skala gejala pernapasan (RSS) dan kepadatan sputum Pa. Proses penelusuran pustaka melalui PUBMED menggunakan kata kunci Aztreonam dan Cystic Fibrosis dengan Boolean operator “AND”. Penelitian yang terpilih sebanyak enam penelitian dengan kriteria berupa RCT, pasien segala usia, pasien CF dan membandingkan aztreonam lysin untuk inhalasi (AZLI) dengan plasebo atau aztreonam lysin untuk inhalasi (AZLI) dengan larutan tobramicin nebulizer (TNS. Dari enam studi yang membandingkan penggunaan aztreonam pada pasien CF, didapatkan empat studi (66,7%) yang menunjukkan kenaikan rerata FEV secara signifikan. Studi terkait juga menilai bahwa pemberian aztreonam dapat menurunkan kepadatan sputum terhadap bakteri patogen Pa dan memperbaiki gejala pernapasan jika ditinjau berdasarkan kenaikan pada skoring CFQ-RSS, pemberian aztreonam dapat ditoleransi dengan baik oleh pasien sehingga dapat dipertimbangkan oleh praktisi untuk dapat digunakan pada terapi CF.
Analisis Penggunaan Antibiotik pada Pasien Covid -19 Di Ruang Isolasi Rumah Sakit X Tipe D Kabupaten Malang Retno Juwita Sari; Rika Yulia; Fauna Herawati
Jurnal Kesehatan Komunitas Vol 9 No 2 (2023): Jurnal Kesehatan Komunitas
Publisher : LPPM Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol9.Iss2.1268

Abstract

COVID-19 cases by the end of 2019 have raised the number of respiratory tract infections; in addition, coinfection during COVID-19 pandemic is associated with disease severity, consequently,causes the number of deaths to surge. The use of antibiotics during the pandemic has evidently improved in a significant way, similar to the increased number of broad-spectrum prescriptions. This phenomenon potentially elevates the number of Antimicrobial Resistance (AMR); therefore, it is necessary to fortify supervision over the use of antibiotics during COVID-19 pandemic. Referring to this, the objective of the study is to evaluate the use of antibiotic during COVID-19 pandemic. This is an observational study conducted on adult subjects with confirmed COVID-19, with moderate to severe level of disease, whose data was collected retrospectively during the period of April 2020 – March 2021. The result confirmed 146 patients were treated as sample of the study, most of whomwere male (53.4%),and female was 46.6%.  The highest age group was 56 – 65 years old by 28.8%. The increase in leukocyte level > 1.000 was 31.5%. 8 (eight) types of antibiotics were used in high frequency, such as, injection levofloxacin antibiotics (50%),while frequently used combination antibioticswere ceftriaxone and levofloxacin (5.5%). Based on quantitative analysis, the total value was 60,54 DDD/100 patient-days, and the value of antibiotic with the highest DDD was levofloxacin 26.51 DDD/100 patient-days. Additionally, the result of analysis on the quality of antibiotics using Gyssens flowchart suggested 36.3% of the given antibiotic were considered as rational (category 0) and 46.6% of the given antibiotics had no indication of usage (category V). Prospective research is needed regarding the use of antibiotics.
Co-Authors Retno Juwita Sari Rika Yulia Sahrul Riadi