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Rani Ardiani
Institut Kesehatan Deli Husada
Medicine & Pharmacology

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EFEKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN EKSTRAK ETANOL DAUN KELAPA SAWIT(Elaeis guineensis Jacq.)TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH Rani Ardiani
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.321

Abstract

African leaves (Gymnanthemum amygdalinum Del.) And palm oil leaves (Elaeis guineensis Jacq.) Have been shown to contain flavonoid compounds, where they are efficacious as antidiabetic. This study aims to determine the combined effectivenessof ethanol extract of African leaves and palm oil leaves as antidiabetic in white rats.The study was conducted using the method of alloxan induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of african leaves and oil palm leaves 25 + 25 mg/kg weight, group II combination of ethanol extract of african leaves and palm oil leaves of 50 + 50 mg/kg weight, group III combination of ethanol extract of African leaves and leaves of oil palm 100 + 100 mg/kg weight for 15 days. Examination of antidiabetic effects is done by comparing the KGD value of the rats before and after treatment. The results of this study indicate that the three doses have antidiabetic effects. Data on the differences in the KGD of rats were carried out statistically using the Shapiro Wilk normality test and the Levene homogeneity test and continued with the ANOVA test. The conclusion of this study is that the dose is the most effective in reducing blood glucose levels in rats, which is a dose of 100 + 100 mg/dl because it mostly decreases blood glucose levels.
UJI EFEKTIVITAS EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) SECARA Topical UNTUK Reepitelisasi PENYEMBUHAN LUKA INSISI PADA TIKUS PUTIH (Rattus norvegicus) Rani Ardiani
Jurnal Penelitian Farmasi & Herbal Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v4i1.750

Abstract

The krokot is a weed that usually grows in plantations. In scientific language, purslane is called Portulaca oleracea L. Purslane is well-known as a nutritious plant in several countries such as China, Mexico, and Greece. In Indonesia, purslane is also known to have uses, or a substitute for ginseng. This aims of the study to determine the effectiveness of purslane herb ethanol extract ointment on wound healing in white rats. This research was conducted using an experimental method. In this study, phytochemical screening and simplicia characterization were carried out. Incision wound healing effect was tested on 25 male white rats with 5 treatment subgroups, namely positive control, negative control, purslane herb ethanol extract ointment 10%, purslane herb ethanol extract ointment 20%, purslane herb ethanol extract ointment 30%. The ointment base used is Vaseline album, liquid paraffin, and solid paraffin. All formulations of purslane herb 10%, 20% and 30%, met the requirements for evaluation of ointment preparations. Phytochemical screening results showed positive containing flavonoids, tannins and saponins. The results of the characterization of purslane herb simplicia powder obtained water content of 8.37%, water soluble extract content of 11.35%, ethanol soluble extract content of 10.99%, total ash content of 7.46% and acid insoluble ash content of 0.88%. The average results of observation of incision wounds in white rats were concentrations of 10% (22 mm) for 14 days, 20% (0.1 mm) for 14 days, 30% (0.04 mm) for 14 days. While the positive control (betadine ointment) was (0 mm) and the negative control (ointment base) was (0.42 mm). It can be concluded that purslane herb ethanol extract can provide effectiveness and antioxidants for wound healing in white rats. The purslane herb 30% ethanol extract has almost comparable effectiveness with betadine ointment in healing incisional wounds in white rats.
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL RUMPUT MUTIARA (Hedyotis corymbosa L. Lamk) TERHADAP TIKUS PUTIH Rani Ardiani
Jurnal Penelitian Farmasi & Herbal Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i1.858

Abstract

Inflamation is the body’s defense mechanism in response to tissue injury and interference by external factors. Pearl grass (Hedyotis Corymbosa L.Lamk) is one of Rubiaceae family. Pearl grass have efficacy in the treatment as anti-inflamatory, anti-diabetic, anti-bacteria, and antioxidant. Pearl grass contains flavonoids has pharmacological effects as a anti-inflamatory. The purpose of this study was to determine the anti-inflamatory effect of ethanolic extract of pearl grass (EERM) on white rats incuded by λ- carragenan.This research was conducted by experimental method which included pearl grass extraction, phytochemical screening, and anti-inflamatory activity test of ethanolic of pearl gras with paw edema method using digital plethysmometer. As experimental animals 15 rats were divided into 5 groups, each group were 3 rats. As an inductor λ-carragenan 1 % was administered intraplantar. Sodium carboxy methyl cellulose (Na-CMC) 0,5 % as negative control, 2,25 mg/kg bw diclofenac dose as positif control and ethanolic extract of pearl grass dose 100 mg/kg bw, dose 200 mg/kg bw, and dose of 400 mg/kg bw as a test material given orally. Observations were made for 6 hours. The test data were analyzed statistically using one way ANOVA and continuced with Tukey’s B.The results of phytochemical indicated that ethanolic extract of pearl grass contained alkaloids, flavanoid, saponins, tanin and glycosides. The dosage of ethanolic extract of pearl grass 100 mg/kg bw, dose 200 mg/kg bw, dose 400 mg/kg bw has the effect as anti-inflamatory. The effective dose of ethanol extract of pearl grass as an anti-inflamatory in white rats was 400 mg/kg bw.
FORMULASI DAN UJI EFEKTIVITAS SEDIAAN KRIM EKSTRAK DAUN KELOR (Moringaoleifera) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH JANTAN (Rattus novergicus) Rani Ardiani
Jurnal Penelitian Farmasi & Herbal Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i2.1212

Abstract

Burns are iinjuries ito ithe iskin ior iother iorganic itissue imainly icaused iby iheat ior idue ito iradiation, ifriction ior icontact iwith ichemicals. i iOne iof ithe iplants ithat ihave ithe ipotential ias ia iburn itreatment iis iMoringa ileaves. i iIn iMoringa i(Moringaoleifera) ileaves, iflavonoid ichemical icompounds ican iact idirectly ias iantibiotics iby iinterfering iwith ithe ifunction iof imicroorganisms isuch ias iburns. Objective to idetermine ithe imost ieffective iconcentration iof iMoringa i(Moringaoleifera) ileaf iethanol iextract ifor ihealing iburns iin imale iwhite irats. Methodirats ithat ihave ibeen ianesthetized iwith ilidocaine imuscularly. i Wounds iin rats iwere imade iby iattaching ia iheated i1 ix i1 icm istainless iplate. i iOn ithe ibacks iof irats iwhose ifur ihas ibeen ishaved iand iaffixed ito ithe iplate ifor i30 iseconds ito iform iblisters ior iburns, ithen ithe ipositive icontrol iconcentration igroup iis iapplied iwith ibioplacenton, ithe inegative icontrol iis ismeared iwith icream ibase, iand ithe itest igroup iis ismeared iwith iconcentrated iMoringa ileaf iextract icream i5%, i10% iand i.15%. i iThe ismearing iof iall itreatment igroups iwas icarried iout ievenly i3 itimes ievery iday, iobserving ichanges iin iburns ifor i14 idays. \ Results ithere iwas ia ireduction iin iburn ilength iat ieach iconcentration. i iThe ipositive icontrol ishowed ithe ifastest ireduction ievery iday ibecause iit icontained placenta extract and neomycin sulfate, in the negative control the wound healing was quite long from the wound diameter because it only used a cream base that did not contain nutritious substances. And at a concentration of 15% faster in the wound healing process. Conclusion:Moringa leaf ethanol extract at a concentration of 15% was the most effective in healing burns in male white rats compared to concentrations of 5% and 10%.
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