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Isa Khaheshi
Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Medicine & Pharmacology

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Pulmonary Hypertension and Its Determinants in β-thalassemia Major and Intermedia Considering Left Ventricular Functional State Behzad Farahani; Abbas Fadaii; Isa Khaheshi; Forooz Baktash; Mohammad Amin Abbasi; Ronak Mohammadi; Koosha Paydary
International Journal of Cardiovascular Practice Vol. 1 No. 1 (2016)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20286/ijcp-010107

Abstract

Introduction: Pulmonary hypertension (PHT) is a common complication in β-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with β thalassemia Major (TM) and β-thalassemia Intermedia (TI), considering left ventricular function.Methods: Pulmonary hypertension (PHT) is a common complication in β-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with β thalassemia Major (TM) and β-thalassemia Intermedia (TI), considering left ventricular function.Results: The overall prevalence of PHT in TM and TI group was estimated to be 35.2% and 29.3%, respectively; while reduced LVEF was evident in 22.7% and 10.1% of patients with TM and TI, respectively. No significant correlation was observed between mean PAP and LVEF in the patients with TI (Pearson coefficient = -0.096, P value = 0.345); while, an adverse association was revealed between mean PAP and LVEF in patients with TM (Pearson coefficient = -0.227, P value = 0.033). Upon univariate analysis, the only significant association was observed between LVEF and pulmonary hypertension among TM patients (P value = 0.001).Our results did not indicate that male gender and aging may affect the development of PHT.Conclusions: According to our findings, a considerable proportion of patients with TM and TI may have PHT. We detected an adverse association between mean PAP and LVEF in patients with TM. Left ventricular function was reduced in patients with PHT among TM group.
Chronic Total Occlusion-Angioplasty with Antegrade Approach: A two-Year Experience in “Modarres Hospital”, A Tertiary University Hospital, Tehran, Iran Morteza Safi; Mohammad Hasan Namazi; Hamid Sadeghi; Habibollah Saadat; Hossein Vakili; Saeed Alipour Parsa; Isa Khaheshi; Bahar Ataeinia
International Journal of Cardiovascular Practice Vol. 1 No. 3 (2016)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21859/ijcp-010307

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Introduction: New techniques for the percutaneous treatment of coronary chronic total occlusions (CTO) have had a high success rate since a few years ago, so the interest for this treatment has been increasing these days.Methods: The current observational study was performed in Modarres hospital as a tertiary referral center. All the patients with documented stable angina who had failed to response to full guideline-mediated medical therapy, referred to our hospital, were candidates for coronary angiography. Antegrade strategy was applied for all these patients. The length of the lesion, the fluoroscopy time of the CTO angioplasty, consumed contrast volume, the number of guide wires used, whether a corsair or tornus micro-catheter was used or not, and the success rate of the angioplasty were documented for further analysis.Results: A total of 47 patients with documented stable angina were finally included. The median age was 59 (45-78) and 70.2% were male. The mean length of the lesion was 34.0 ± 1.1 .The mean fluoroscopy time and contrast volume were 57.9 ± 3.2 minutes and 525.9 ± 20.9 mL, respectively. In average, 2.2 guide wires were used. Corsair and tornus micro-catheters were applied in 30 (63.8%) and 5 (10.6%) of the cases, respectively. Seven complications (all including coronary dissection) occurred. In-hospital major adverse cardiac events (MACE) rate was 10.6%, all of which were non-Q wave myocardial infarction. The success rate was 85.1%. The higher number of used wires, use of corsair, and tornus micro-catheter were not significantly concordant with success rate (P-value > 0.05); in addition, longer lesion was not concordant with unsuccessfulness rate (P-value > 0.05).Conclusions: Patient selection for CTO-angioplasty should be performed more carefully. Patients’ quality of life and risk of probable procedural complications and future cardiac events should be assessed to decide the best treatment approach. Radiation exposure, contrast consumption and fluoroscopy time are recommended to be monitored during the procedure and thresholds should be defined to enhance safety and efficacy.
Is It Time to Review our Educational Program for the Electrocardiography Operators? Habibollah Saadat; Hossein Tajdini; Zahra Saadat; Vahid Eslami; Mehdi Sheibani; Babak Sharifkashani; Roxana Sadeghi; Isa Khaheshi
International Journal of Cardiovascular Practice Vol. 2 No. 3 (2017)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21859/ijcp-020302

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Co-Authors Abbas Fadaii Babak Sharifkashani Bahar Ataeinia Behzad Farahani Forooz Baktash Habibollah Saadat Hamid Sadeghi Hossein Tajdini Hossein Vakili Koosha Paydary Mehdi Sheibani Mohammad Amin Abbasi Mohammad Hasan Namazi Morteza Safi Ronak Mohammadi Roxana Sadeghi Saeed Alipour Parsa Vahid Eslami Zahra Saadat