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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)
Mawardi Ihsan
Department of Pharmacology and Clinical Pharmacy, Universitas Gadjah Mada, Yogyakarta
Health Professions Medicine & Pharmacology Public Health

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Drug Dosing Rationality Based on Jelliffe Equation in Acute Kidney Injury Dealinda Husnasya; Mawardi Ihsan
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 8, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (657.369 KB) | DOI: 10.22146/jmpf.39921

Abstract

Patients with Acute Kidney Injury (AKI) experience changes in unstable kidney function which is characterized by instability of serum creatinine values that affect the concentration of drugs in the body. Therefore, adjusting the dosage and frequency of the drug is an important concern. This study aimed to determine the proportion of rational drug dosage regimens in hospitalized patients with AKI. This research was a retrospective observation study with cross sectional design. Sample collection was carried out using simple random sampling method for patients who were hospitalized with AKI during January 1st till December 31, 2017. Data analysis was carried out descriptively to see the proportion and description of the rationality of each dosage regimen given to patients. This research was conducted at the dr. Sardjito General Hospital Yogyakarta. The results showed that the proportion of rational drug dosage regimens given to 100 inpatients with AKI was 60.00% based on literature and 94.12% based on predictive steady-state concentration calculation. Irrationality of the dosing regimen because of administration interval was 52.84%; because of dose was 17.05%; and because of both were 30.11%. The irrationality based on predictive steady concentration showed that drug concentration below minimum effective concentration was 33.33% and over minimum toxic concentration was 66.67%. The proportion of rational drug dosage regimens given to 100 inpatients with AKI based on literature and calculation of predictive steady-state concentrations were quite high. However, some dosing regimens were still irrationally prescribed with the irrationality form were generally in the form of irrational delivery interval with excessive drug concentration.
Hubungan antara Drug-Related Problems dan Lama Rawat Inap pada Pasien dengan Diabetes Tipe 2 Surya Yuli Astuti; Mawardi Ihsan; Fita Rahmawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (694.717 KB) | DOI: 10.22146/jmpf.43576

Abstract

Drug-Related Problems have been associated to blood glucose control along with the morbidity and mortality of type 2 diabetes patients through previous studies. However, studies that associate Length of Stay (LOS) with DRPs in type 2 diabetes patients have not been done. The study that had been done was to associate between LOS and Medication Errors (ME). Medication errors include DRPs because other researchers state that errors are also kind of problem. This study was aimed to identify Drug-Related Problems (DRPs) and to associate between DRPs and LOS in type 2 diabetes patients who were hospitalized. This study was a prospective observation study with a cross-sectional design. Sample collection was carried out by consecutive sampling method in type 2 diabetic patients hospitalized in internal medicine ward in one academic hospital in Yogyakarta. Data analysis was done descriptively to see DRPs description and the association between DRPs and LOS was analyzed using Chi-square or Fisher's exact test whenever Chi-square test conditions were not met. Data collection was carried out in January till April 2018. The results showed that the DRPs in hospitalized type 2 diabetic patients were 80.56% with unnecessary drug therapy occurring at 34.72%; dosage too low of 25%; needs additional drug therapy 13.38%; dosage too high 12.5%; ineffective drug 11.11%; and there was no association seen between DRPs and LOS.
Co-Authors Dealinda Husnasya Fita Rahmawati Surya Yuli Astuti