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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Asian Australasian Neuro and Health Science Journal (AANHS-J)
Abdurrahman Mouza
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Hubungan raeseptor estrogen dengan Ki-67 labeling index pada meninagioma intrakranial Abdurrahman Mouza; Iskandar Japardi; Suzy Indharty
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction : Meningioma occurs more in women than men with ratio 2 : 1. Mitosis of meningioma is stimulatedbyfewgrowth factorsand one of itis estrogen. Expression of estrogen receptor on meningioma showsthat clinical meningioma has characteristic more aggressive. Proliferation Index can be measured by antibody of Mind Bomb (MIB-1) binding Ki-67 antigen. Ki-67 is showed on the cells which proliferating through cells cycle.Relation between estrogen receptor and cell proliferation is interesting because it has controversy.Method : This Study used Cross Sectional method for analising relation between estrogen receptor and Ki-67 in patients have been diagnosed meningioma. This study has been done at general hospital H. Adam Malik Medan and laboratorium of patologi anatomi at Murni Teguh hospital.This study did in Oktober-November 2013.Result : In this study is almost meningioma grade I stained Ki-67 not have mitosis with amount 13 sample (43.3%) or positive mitosis is 14 sample (45%). While immunohistochemistry staining of estrogen receptor on meningioma grade I has 25 negative sample (83.3%) and 14 positive sample (51.8%). All of grade I and II are negative.Relation of these staining was used Chi-Square with limit value p<0.05. This result is p=0.677 that shows no significance relation between estrogen receptor and labeling Index Ki-67.Conclusion : These histopatology have many frequents type that is 16 cases of meningothelial meningioma (53.3%), fibroblastic meningioma, and 4 cases transitional meningioma (13.3%). The result is no relation between estrogen receptor and Ki-67 with p=0.667 (p>0.05).Other results are no relation Ki-67 with age p=0.204 (p>0.05) and sex p=0.121 (p>0.05). Keywords : estrogen receptor, Ki-67, meningioma
Global Ischemic in A 3-Months-Old Child with Hydrocephalus : A Case Report of Good Outcome Syekh Ahmad Arafat; Fahmi Rasyid Sihombing; Muhammad Ihsan Z. Tala; Abdurrahman Mouza
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 7 No. 03 (2025): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhs-j.v7i03.20427

Abstract

Introduction. Ventriculomegaly causes compression within the cranial vault, which increases intracranial pressure and leads to severe brain damage. Usually progressive. if untreated, may be fatal. Case. 3-month-old male child with increasement of head circumference for 2 months. Fever, cough, cold, vomiting, seizure was not found. MRI show extensive dilatation of ventricular system wide-open foramen of Luschka and Magendie with thinning of cerebral cortex and also global ischemic hypoxia. Discussion. The CBF is regulated by the Monroe-Kellie doctrine which state that space of the cranial cavity is fixed in volume. Congenital hydrocephalus occurs in one in 500-1000 babies born in the United States. Lipid peroxides, formed by oxygen free radical damage to membranes, have been detected in hydrocephalic brains by detection of thiobarbituric acid reactive substances. The mechanism of periventricular axon damage includes calcium mediated activation of proteolytic calpains that damage cytoskeletal proteins, similar to the processes that follow acute traumatic or ischemic injury. The gold standard permanent treatment for hydrocephalus is CSF diversion by placement of a shunt. A shunt has three basic component parts: a ventricular catheter placed in the lateral ventricle, a valve regulating the flow of CSF out of the brain, and a distal catheter that terminates in a cavity. The most common shunt, a ventriculoperitoneal shunt (VPS), has been well accepted since its inaugural use. Surgical treatment is associated with a 50% reduced risk of death overall
Co-Authors Fahmi Rasyid Sihombing Iskandar Japardi Muhammad Ihsan Z. Tala Suzy Indharty Syekh Ahmad Arafat