Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Nusantara The Journal Of Medical School
Dippan Hutapea
PPDS Ilmu Bedah Fakultas Kedokteran Universitas Sumatera Utara, RSUP. H. Adam Malik Medan
Health Professions Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Perbedaan Ekspresi Reseptor Hormonal Antara Pasien Premenopausal dan Postmenopausal Pada Kanker Payudara di RSUP H. Adam Malik Medan Dippan Hutapea; Emir Taris Pasaribu; Suyatno Suyatno
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 49, No 2 (2016): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1526.156 KB)

Abstract

Introduction: Determination of Hormonal receptors is of utmost importance in planning therapy in patients with breast cancer. Breast cancer ussualy develops in perimenopausal and postmenopausal women and only several cases before age 25. Endogenous excess also plays role in the onset of breast cancer,  particularly in women with prolong reproduvtive periode, nulliparae, and those first delivery at an older age. The aim of the study was to assess the difference expression of estrogen receptors (ER) and progesterone receptors (PR) premenopausal and postmenopausal in breast cancer patient.Method :  This study  was analitic cross sectional included 245 patient treated at Oncology Surgery Division, Departemen of Surgery Medical Faculty USU – RSUP H. Adam Malik, between Januari 2013 until Mei 2015. ER and PR status was determine by Immunohistochemistry (IHC) from paraffin block.Result : From this researh the result of the premenopausal patients 137 (55.9%), postmenopausal 108 (44.1%). The frequency of premenopausal with ER + and PR +, 33 (24.1%) and postmenopausal 25 (23.1%). There was no significant different between ER and PR expression, tumor size and differentiation from histopathology grading between premenopausal and postmenopausal patient (p>0.05) in this research. And also in this research there was significant comparison between ER + PR + (Hormone dependent carsinoma) with premenopausal and postmenopausal with p value 0.043.Conclusion : From this research the hormonal expression receptor of ER and PR is higher in the premenopausal patient than the postmenopausal patient, but have no significant result in statistic.Keywords :  Estrogen Receptor, Progesteron Receptor, Premenopausal, Postmenopausal.
Co-Authors Emir Taris Pasaribu Suyatno Suyatno