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All Journal journal of internal medicine INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana E-Jurnal Udayana Medica Jurnal Penyakit Dalam Udayana
I Wayan Sudhana
Divisi Ginjal Dan Hipertensi, Bagian Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Udayana-RSUP Sanglah Denpasar
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : journal of internal medicine

 1 
HUBUNGAN ANTARA PRODUK KALSIUM X FOSFAT SERUM DENGAN PENYAKIT ARTERI PERIFER PADA PASIEN HEMODIALISIS REGULER DI RSUP SANGLAH DENPASAR Wulandari, Dewi Catur; Raka Widiana, I G; SL, Jodi; Sudhana, I W; Suwitra, Ketut
journal of internal medicine Vol. 8, No. 2 Mei 2007
Publisher : journal of internal medicine

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Abstract

Peripheral Arterial Occlusive Disease (PAOD) is common among patients undergoing hemodialysis (HD). In the generalpopulation, DM, male, cigarette smoking, advanced age, hypertension and dyslipidemia are the most important risk factorsfor PAOD. Recently, some studies in patients with regular HD found evidences that PAOD associated with increase of calciumand phosphate serum level and increase of Ca.P product due to secondary hyperparatiroidism. A cross-sectional study was doneon 46 regular HD patients to evaluate prevalence of PAOD among patients who are undergoing regular HD and their associationbetween Ca.P product. Morning fasting plasma were taken for lipid profile, blood sugar, blood urea nitrogen, serum creatinin,albumin level, Ca, inorganic P. Ankle-brachial index (ABI) of blood pressure as measured after dialysis session using Va-SeraVS-100. Fourty six (26 males, 20 females) regular HD patients, age 50.95 ± 9.90 years, duration of HD 27.7 ± 22 months wereincluded in this study. Using ABI < 0.9 as cut off value for the presence of PAOD, 15.2% had PAOD. Means of Ca serum levelwas 9.04 ± 0.76 mg/dl, phosphate serum level was 56.48 ± 23.90 mg/dl. Using 55 or more as cut off value for abnormal concentrationof Ca.P product, 47.7% patients had abnormal Ca.P product. Three of 21 patients with Ca.P 55 had PAOD and 4 of 23patients with Ca.P < 55 had PAOD ( OR 0.79 with 95% CI : 0.15 ? 4.04 for patients with Ca.P < 55 ). Using logistic regression tocontrol Ca and P levels, Ca.P 55 tend to associate with increased risk of PAOD (OR 6.22 ; 95% CI : 0.23 ? 167.71)More than fifteen percent of patients with regular HD had PAOD. More than fourty seven percent of patients had abnormal Ca.P.Patients with Ca.P 55 tend to associated with increased risk of PAOD (OR 6.22 ; 95% CI : 0.23 ? 167.71)
EVALUASI PROSPEKTIF KADAR NEUTROPHIL GELATINASE- ASSOCIATED LIPOCALIN URIN DAN KREATININ SERUM PASIEN ACUTE KIDNEY INJURY PASKA PEMBEDAHAN Arya Nugrah, Putu; Sudhana, I Wayan
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

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Abstract

Acute Kidney Injury (AKI) is a common clinical nding that produces some serious health problem. Since the previouslydecades, the identication of AKI clinical practically based on laboratory test as Blood Urea Nitrogen (BUN) and Serum Creatinin (SC). Unfortunatelly, SC is not a reliable indicator of AKI in acute phase. Neutrophil Gelatinase-AssociatedLipocalin (NGAL) is promisingly for an early biomarker of ischemic kidney injury. After performing the inclusion criteriaand exclusion criteria, samples are underwent the operation then admitted to the ICU ward. Samples were followed andunderwent serially laboratory examination of urine NGAL, SC and urine output according to the timetable of the research.Mean concentration of SC before operation and hour 0 hour, 6 hours, and 24 hours after operation for non AKI patientswere as follow 0.83 ± 0.19 mg/dl; 0.83 ± 0.19 mg/dl; 0.89 ± 0.18 mg/dl; and 0.88 ± 0.25 mg/dl. And for AKI patients were0.86 ± 0.21; 0.81 ± 0.20 mg/dl; 1.01 ± 0.20 mg/dl; and 1.84 ± 0.75 mg/dl. Mean concentration of urine NGAL on 0 hour, 3hours, and 6 hours post operation non AKI patients were as follows 26.0 ± 27.7 ng/l; 24.4 ± 23.0 ng/l; and 32.6 ± 42.4 ng/l.While in AKI patients were 809.4 ± 379.0 ng/l; 732.0 ± 450.0 ng/l; and 651.4 ± 432.0 ng/l. The elevated concentration ofurine NGAL among cases of AKI occurred earlier than the elevated concentration of SC.
Co-Authors Dewi Catur Wulandari Fernanda Savitri Mega Pratistha I Gde Raka Widiana I Gusti Bagus Aginda Dwi Pawana I Putu Arya Narayana I Putu Bagus Muliartha I Putu Bayu Triguna I Putu Restu Wira Dharma I Wayan Losen Adnyana Jodi SL Ketut Suwitra Luh Putu Previyanti Dharma Putri MADE RATNA SARASWATI . Made Yudha Ganesa Wikantyas Widia Ni Luh Made Novi Ratnasari Ni Made Vina Septiani Nyoman Arya Shridewi Abhigamika Nyoman i Dianita Candradew Pande Putu Adnyani Pratistha, Fernanda Savitri Mega Putri Rossyana Dewi Putu Arya Nugrah Putu Shinta Widari Tirka SUMARNO Susanty Wahyu Nanurlaili