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All Journal JURNAL ILMIAH KESEHATAN SANDI HUSADA Jurnal Ilmiah Kesehatan Sandi Husada
Vira Katya Aurelia
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Health Professions Nursing Public Health

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Glutathione sebagai pemutih kulit Vira Katya Aurelia
Jurnal Ilmiah Kesehatan Sandi Husada Vol 8 No 2 (2019): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v10i2.131

Abstract

GSH is one of the compounds that inhibits melanin production by inhibiting tyrosinase activity. Antimelanogenic properties of glutathione have resulted in doctors often giving it as a "miracle" medicine for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. However, its uncontrolled use, especially as a parenteral formulation, seems unjustified, given the lack of research in supporting this theory. Although there are mechanisms that inhibit the process of melanogenesis by considering the side effects in the form of impaired liver function. Its safety as an intravenous drug is also questionable. The use of Gluthatione as a skin lightening agent, either topically, orally, or intravenously shows mixed results in an enlightening effect. Further research must be carried out to ensure the safe use of this substance, some studies report that oral use shows better effectiveness than topical or intravenous, but the side effects that are also dangerous such as impaired liver function
Glutathione sebagai pemutih kulit Vira Katya Aurelia
Jurnal Ilmiah Kesehatan Sandi Husada Vol 8 No 2 (2019): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v10i2.131

Abstract

GSH is one of the compounds that inhibits melanin production by inhibiting tyrosinase activity. Antimelanogenic properties of glutathione have resulted in doctors often giving it as a "miracle" medicine for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. However, its uncontrolled use, especially as a parenteral formulation, seems unjustified, given the lack of research in supporting this theory. Although there are mechanisms that inhibit the process of melanogenesis by considering the side effects in the form of impaired liver function. Its safety as an intravenous drug is also questionable. The use of Gluthatione as a skin lightening agent, either topically, orally, or intravenously shows mixed results in an enlightening effect. Further research must be carried out to ensure the safe use of this substance, some studies report that oral use shows better effectiveness than topical or intravenous, but the side effects that are also dangerous such as impaired liver function
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