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All Journal Medula JURNAL ILMIAH KESEHATAN SANDI HUSADA Jurnal Ilmiah Kesehatan Sandi Husada
Kuntum Sureda
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Bone Marrow-Derived Mesenchymal Stem Cell (BM-MSC) Sebagai Sumber Alternatif Sel Blastema Terhadap Regenerasi Anggota Tubuh Kuntum Sureda
Jurnal Ilmiah Kesehatan Sandi Husada Vol 8 No 2 (2019): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v10i2.182

Abstract

Limb regeneration is initiated by blastema cells (BC) and related genes that are only present in mammals confined to the distal fingertips of the phalangeal terminals and neonates. If amputated to proximal phalangeal, regeneration will fail due to lack of blastema cells (BC) in adults and difficulty in isolating and using blastema cells (BC) from neonates. BM-MSC has succeeded in increasing its ability to regenerate various wound tissue and its healing properties, because of this BM-MSC is used as an alternative cell source that produces blastema cells (BC). The original blastema cells (BC) that isolated from neontus and blastema cells (BC) in BM-MSC were compared to the ability of colony formation, cell proliferation, alkaline phosphatase activity (ALP), calcium supply, and osteogenic gene expression. The ability to form colonies was significantly higher in BM-MSC compared to original BC (P <0.05). Alizarin red stain (ARS), calcium and ALP tests show higher levels of mineral deposition in BM-MSCs. The qRT-PCR analysis revealed cells from both sources were ready to differentiate into mesodermal lineages. The rate of expression of osteblastic markers shows the capasity of bone differences is higher at BM-MSC at all time points.
Penatalaksanaan Holistik Dermatitis Atopik Pada An. N Usia 12 Tahun Di Puskesmas Kota Karang Melalui Pendekatan Kedokteran Keluarga Kuntum Sureda; Refi Fandana; Sahab H. Sibuea
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.534

Abstract

Atopic dermatitis also known as eczema is the most common form of chronic dermatitis. This disease is generally synonymous with itching which is characterized by dry skin, chronic lesions, and lichenification. Atopic dermatitis is believed to be associated with other forms of IgE disorders such as allergic rhinitis, asthma, and food intolerance. This disease results in a high rate of morbidity and its prevalence has increased in recent decades. The study conducted is a case report. Data were obtained through history taking and physical examination by conducting home visits. The assessment is carried out based on a qualitative diagnosis, process, and visit. Based on the examination, the patient was a 12 year old girl with atopic dermatitis. Knowledge of patients and families about the disease is very limited. Education and intervention provided to patients and families about atopic dermatitis and risk factors that can trigger the occurrence of this disease. On internal factors in cases such as genetic factors, age factors, and ignorance of the originator. External factors are the lack of family knowledge about atopic dermatitis, its complications and the environment that has many allergens. Pharmacological and non-pharmacological interventions are carried out in the form of education in preventing the onset of atopic dermatitis symptoms in patients. In the evaluation of increasing patient compliance to avoid risk factors and family knowledge about patient care. Services with a family medicine approach in pharmacological and non-pharmacological therapy are able to solve health problems and improve the patient's quality of life.
Bone Marrow-Derived Mesenchymal Stem Cell (BM-MSC) Sebagai Sumber Alternatif Sel Blastema Terhadap Regenerasi Anggota Tubuh Kuntum Sureda
Jurnal Ilmiah Kesehatan Sandi Husada Vol 8 No 2 (2019): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v10i2.182

Abstract

Limb regeneration is initiated by blastema cells (BC) and related genes that are only present in mammals confined to the distal fingertips of the phalangeal terminals and neonates. If amputated to proximal phalangeal, regeneration will fail due to lack of blastema cells (BC) in adults and difficulty in isolating and using blastema cells (BC) from neonates. BM-MSC has succeeded in increasing its ability to regenerate various wound tissue and its healing properties, because of this BM-MSC is used as an alternative cell source that produces blastema cells (BC). The original blastema cells (BC) that isolated from neontus and blastema cells (BC) in BM-MSC were compared to the ability of colony formation, cell proliferation, alkaline phosphatase activity (ALP), calcium supply, and osteogenic gene expression. The ability to form colonies was significantly higher in BM-MSC compared to original BC (P <0.05). Alizarin red stain (ARS), calcium and ALP tests show higher levels of mineral deposition in BM-MSCs. The qRT-PCR analysis revealed cells from both sources were ready to differentiate into mesodermal lineages. The rate of expression of osteblastic markers shows the capasity of bone differences is higher at BM-MSC at all time points.
Co-Authors Refi Fandana Sahab H. SIbuea