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All Journal Jurnal Kedokteran Indonesia Nexus Kedokteran Klinik
Hadi Sudjito
FK. UNS/ RSUD Moewardi
Medicine & Pharmacology

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Penambahan Dexmedetomidine Memperpanjang Lama Kerja Anestesi Blok Aksilaris Osi, ; Sudjito, Hadi; Murti, Bhisma
Jurnal Kedokteran Indonesia Vol 3, No 1 (2012)
Publisher : Jurnal Kedokteran Indonesia

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Background:Dexmedetomidine is alpha 2 adrenergic receptor agonist that produces analgesia by suppressing norepinephrin secretion and blocking nerve action potential in alpha 2 receptor. This study aimed to determine if addition of dexmedetomidineof  25 µg  dexmedetomidine into 30 mL bupivacaine 0.25% shortens onset and prolongs duration of axillary block anesthesia. Methods: This phase III clinical study used double blinded randomized controlled trial design. A sample of 22 adult patients of ASA I and II were scheduled for lower arm surgery with axillary block. Patients were randomized into 2 groups. Patients in group B ( n = 11) were given 30 mL bupivacaine 0.25% and normal saline. Patients in group D (n = 11) were given 30 mL bupivacaine 0.25% and dexmedetomidine 25 µg. Results: The onset of sensory (p=0.765) and motor (p=0.748) blockade was not significantly different. But, the duration of sensory (p<0.001) and motor (p<0.001) blockade was significantly longer in group D than group B. The side effect of dexmedetomidine administration is bradycardia. Conclusion: The addition of 25 µg dexmedetomidine into 30 mL bupivacaine 0.25%does not shorten onset, but prolongs duration of sensory as well as motor blockade in axillary block anesthesia. Keywords: Dexmedetomidine, bupivacaine, axillary block, onset of sensory and motor blockade, duration of sensory and motor blockade.
Perbedaan Perubahan Tekanan Darah Arteri Rerata antara Penggunaan Diazepam dan Midazolam sebagai Premedikasi Anestesi Wicaksono, Bagus; Donda, Melissa; Sudjito, Hadi
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Diazepam and midazolam is used as premedication for anesthesia. Diazepam and midazolam as the benzodiazepine drugs can cause changes in mean arterial pressure. This study aimed to prove the difference in mean arterial pressure changes between diazepam and midazolam as premedication for general anesthesia. Methods: This was an observational analytic study with cross-sectional method. Using consecutive sampling, we selected patients who fulfill the inclusive and exclusive criterias. Thirty patients were selected and divided into group of diazepam and midazolam. The first group was given diazepam 0.07 mg/kg intravenously and the second group was given midazolam 0.07 mg/kg intravenously. The blood pressure is recorded before giving the premedication and in five minutes after giving the premedication. The differences in mean arterial blood pressure between the two groups were analyzed by independent t-test. Results: The result showed a non-significant difference in mean arterial pressure before the administration (p=0.198, p>0.05) and five minutes after the administration of diazepam and midazolam (p=0.335, p>0.05). Conclusions: There is no significant difference in mean arterial pressure when using premedication of Diazepam and Midazolam administration. Keywords: Diazepam, Midazolam, Mean Arterial Pressure 
Co-Authors Bagus Wicaksono Bhisma Murti Melissa Donda Osi