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Sugeng Juwono Mardihusodo Sugeng Juwono Mardihusodo
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Activity of the combined pyrimethamine and sulphadoxine as antifilarial in Brugia pahangi - Aedes togoi model infection Sugeng Juwono Mardihusodo Sugeng Juwono Mardihusodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 01 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The mortality rates of Aedes togoi mosquito either uninfected or infected with Brugia pahangi maintained in insectary for 12 days with various concentrations of the combined pyrimethamine (P) and sulphadoxine (S) in 10% sugar-water solution: 5 mg% P + 100 mg%, 10 mg% P + 200 mg% S, and 20 mg% P + 400 mg% S significantly increased compared to that of the control groups. The present evidence showed a definite insecticidal action of the combined drugs.Infection and infective rates of Ae. togoi mosquitoes, average number of B. pahangi larvae and infective larvae per infected mosquitoes, average size and movement of the larvae in the groups of mosquitoes treated with various concentrations of the combined drugs for 12 days decreased significantly compared to that of the control groups of mosquitoes. The present evidence demonstrated a definite action of the combined pyrimethamine and sulphadoxine as an antifilarial in B. pahangi Ae. togoi model infection.Key Words: pyrimethamin-sulphadoxine - Brugia pahangi - Aedes togoi - antifilarial - insecticide
Developing and promoting community participation in the control of dengue haemorrhagic fever vectors Sugeng Juwono Mardihusodo Sugeng Juwono Mardihusodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 19, No 01 (1987)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Dengue haemorrhagic fever (DHF) is caused by dengue virus and transmitted by Aedes aegypei and A e. albopictus mosquitoes. The absence of causative drugs and protective vaccines, therefore, indicates vector control measures as the only alternative for the disease abatement. Various methods of dengue vector control and of developing and promoting community participation in such activities are discussed. Key Words: dengue haemorrhagic fever — Aedes aegypti — Breteau Index — environmental sanitation — Rural Improvement Programme
Uji Lapangan Skala Kecil Tentang Pengaruh Kahut Panas Chlorpyrifos Terhadap Nyamuk Aedes aegypti dan Anopheles aconitus Sugeng Juwono Mardihusodo Sugeng Juwono Mardihusodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 20, No 01 (1988)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Sugeng Juwono Mardihusodo, Kasumbogo Dengue Haemorrhagic Fever (DI-IF) and malaria are two major diseases of public health importance in Java, and other areas of Indonesia. Chemical insecticides are still the main weapon in the control of the disease vectors particularly in epidemic situations. In case of malaria vector control, mainly in Java, one of the problems encountered in the field is the development of highly resistant strain of Anopheles aconitus to DDT. Efforts should be taken, therefore, to find a better and more effective insecticide for controlling the vector.Clorpyrifos (Lorsban *180 EC) at doses of 100 ml/ha, 200 ml/ha. and 300 ml/ha applied as thermal fog was proved to be highly effective for controlling Aedes aegypti and An. aconitus mosquitoes, equal to that of malathion at the dose of 438 ml/ha..Considering the effectiveness and efficiency of the control, the recommended dose of chlorpyri - fos for two species of mosquitoes is 100 ml/ha.Key Words: thermal fog — chlorpyrifos — malathion — Aedes aegypti — Anopheles
Current status of filariasis chemotherapy Sugeng Juwono Mardihusodo Sugeng Juwono Mardihusodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 15, No 03 (1983)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Success of filariasis control still depends greatly on chemotherapy. piethylcarbamazine is so far considered as the most suitable and effective drug of filariasis in man. Its untoward reactions experienced by the treated individuals, long course of administration and incapability of removing all Wuchereria bancroftimicrofilariae in blood, however, initiate the search for more ideal antifilarials.A number of chemical compounds has been tested and shown to be active as filaricides in. experimental animals, and needs further intensive and careful clinical evaluation in man prior to its administration on a wider scale.Various methods of filaricide testing, using different filarial parasites and laboratory animals, and hindering factors arising in case of the production of a new antifflarial drug are discussed.Key Words: filariasis chemotherapy - diethylcarbamazine filaricides - filaricide testing - an tifilarial drug
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