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All Journal Proceedings of the International Conference on Applied Science and Health Nursing Care and Health Technology Journal (NCHAT)
Reni Hariyanti
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Education Health Professions Medicine & Pharmacology Nursing Public Health

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WHAT HAPPENS IF THE BROMELAIN IN Ananas comosus L. Merr. GIVEN TO PEOPLE LIVING WITH HIV/AIDS (PLWHA) ? : A REVIEW Reni Hariyanti; Sri Sumarni
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: Human immunodeficiency virus /Acquired immunodeficiency syndrome (HIV/AIDS) is a global problem that requires serious treatment. Antiretroviral therapy (ART) has the potential to cause side effects and drug resistance for people living with HIV/AIDS (PLWHA). Alternative therapies using combination of bromelain and ART to maintain and improve immunity of PLWHA. The objective of the study was to describe the potential of bromelain in pineapple (Ananas comosus (L.) Merr) to increase the immune system of people living with HIV/AIDS. Methodology: The research method used a systematic literature review. The literature that this study used was search through in the Science Direct and Google Schoolar database. The article search used the keyword Ananas comosus (L.) Merr, HIV/AIDS healing pathway or bromelain enzyme healing pathway HIV/AIDS and Pineapple "bromelain enzyme" for HIV/AIDS. Obtained 4 articles from 219 articles published between 2010 until 2019. The article used in this study written in English and Indonesian. Results: The results showed that the bromelain enzyme in pineapple have proteolytic properties that can destroy the protein layers of the HIV viruses. The other benefit are immunomodulators that can increase the immune system of PLWHA by increasing CD4 counts or maintaining the stability of the CD4 count and reducing viral load levels even undetectable. Conclusion: The conclusion of this study is bromelain in pineapple can be used as an alternative cure for PLWHA which do not have side effect and can destroy the HIV virus protein layer and increasing the immune system of PLWHA as well.
Efektivitas Herbal Sebagai Alternatif Terapi Sindrom Ovarium Polikistik (PCOS): Literatur Review Reni Hariyanti; Putri Lestari; Olivia Tri Monica; Ririn Indriani
Nursing Care and Health Technology Journal (NCHAT) Vol. 5 No. 2 (2025): Nursing and Health Care Technology-July to December Period
Publisher : Progres Ilmiah Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56742/nchat.v5i2.153

Abstract

Menurut World Health Organization (2025), sekitar 6–13% perempuan usia reproduksi mengalami PCOS, dengan peningkatan 10–15% akibat gaya hidup tidak sehat dan obesitas. Penelitian ini bertujuan menemukan terapi alternatif yang aman, efektif, dan berkelanjutan. Berdasarkan 6 artikel dari PubMed, Google Scholar, dan Science Direct (2020–2025), beberapa terapi herbal menunjukkan efek positif pada PCOS. Asparagus africanus berpotensi melalui metode docking molekuler, Tinospora cordifolia pada hewan model meningkatkan hormon normal, sensitivitas insulin, dan struktur ovarium, sedangkan Moringa oleifera berperan melalui efek antioksidan, modulasi hormon, perbaikan mikrobiota usus, dan peningkatan folikulogenesis. Urtica dioica dan lutein menurunkan MDA, kadar testosteron, serta meningkatkan SHBG, memperbaiki ketidakseimbangan hormon. Cinnamomum verum dosis 3 g/hari selama 12 minggu menurunkan testosteron total tanpa memengaruhi metabolisme atau progesteron luteal, dan kombinasi labu kuning, bunga matahari, wijen, serta biji rami mampu menyeimbangkan FSH dan LH. Kesimpulannya, Tinospora cordifolia dan Moringa oleifera efektif sebagai terapi PCOS, memberikan dampak positif pada aspek hormonal, metabolik, dan struktural.
Co-Authors Olivia Tri Monica Putri Lestari Ririn Indriani Sri Sumarni