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I Gede Gita Sastrawan
Universitas Udayana
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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CAPSAICIN LOADED NANOLIPOSOME AGONIS TRPV1 : POTENSI TERAPI DALAM PENATALAKSANAAN ATEROSKLEROSIS I Gede Gita Sastrawan
Essence of Scientific Medical Journal Vol 16 No 2 (2018): Volume 16 No. 2 (Juli-Desember) : Essence Of Scientific Medical Journal
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2018.v16.i02.p06

Abstract

Introduction: Atherosclerosis known as the cause most of cardiovascular disease. Atherosclerosis is a complex pathological process that occurs in the blood vessel. This disease can be triggered by lipid modification, which cause chronic inflammation, eventually lead to thrombosis or stenosis.Result and Discussion: Capsaicin loaded nanoliposome was constructed by extracting capsaicin from chili (Capsicum frutescens L.) using Microwave Assisted Extraction (MAE) method. Then the capsaicin extraction results were constructed with nanoliposome using a thin film hydration method. Capsaicin has LD50 in male Swiss albino mice at 190 mg/kg per oral. Once administered orally, hydrophobic capsaicin will pass through the plasma membrane of endothelial cells and lead to the receptor side of the intracellular vanilloid-binding site reseptor TRPV1 (Transient Receptor Potential Vanilloid 1). The activated TRPV1 is capable of increasing the calcium ion influx which affect the increased expression of ATP-binding cassette transporter A1 (ABCA1) and the decreased expression of LRP1 (low-density lipoprotein protective protein 1). Due to increased Ca2+ influx, endothelial TRPV1 activation also increases PKA phosporilation (protein kinase A) which implies increased UCP2 expression resulting in decreased ROS formation and foam cell formation in atherosclerosis.Conclusion: Capsaicin loaded nanoliposome has potential in the management of atherosclerosis.
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