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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research
Tetri Widiyani
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret Biodiversity Reaserch Group, Department of Biosains Postgraduate Programe, Universitas Sebelas
Environmental Science Public Health

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Analgesic Activity of Ethanolic Extracts of Karika Leaves (Carica pubescens) In Vivo Heru Sasongko; Sugiyarto Sugiyarto; Nur Rohman Efendi; Diah Pratiwi; Ahmad Dwi Setyawan; Tetri Widiyani
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (397.239 KB) | DOI: 10.20961/jpscr.v1i2.1938

Abstract

Karika (Carica pubescens)is a typical plant of the Dieng plateau. Previous study showed that Caricapubescenscontains chemical compound such as flavonoid that play role in analgesic activity. This study was aimed to determine the analgesic activity of etanolic extracts of karika leaves) in vivo using writhing method. The study was conducted on 25 male mice strain Swiss-Webster (20-30 g, 2-3 months) that were randomly divided into 5 groups. Group I was given distilled water 1 mL (p.o) as negative control, group II was given tramadol 50 mg/kgBW (p.o) as positive control, and group III-V received an etanolic extracts of karika leaves in 3 doses, i.e. 20 mg/kgBW, 40 mg/kgBW, and 80 mg/kgBW (p.o), respectively. Acetic acid 0,5% (v/v) was used as pain inductor.  The writhe was observed within 1 hour. Data analysis was carried out by using one way ANOVA. The result showed that the ethanol extract of leaves Karika (Carica pubescens) have activity as an analgesic at a dose of 20 mg / kg, 40 mg / kg and 80 mg / KgBW (p <0.05), chemically induced, where a dose of 80 mg / KgBW (p.o) produce the most high analgesic activity.
Co-Authors Ahmad Dwi Setyawan Diah Pratiwi Heru Sasongko Nur Rohman Efendi Sugiyarto Sugiyarto