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L. Sutedja
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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ISOLATION AND ANTIBACTERIAL TEST OF GARLIC OIL A. T. Karossi; M. Hanafi; L. Sutedja
Jurnal Kimia Terapan Indonesia Vol 3, No 2 (1993)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3252.499 KB) | DOI: 10.14203/jkti.v3i2.271

Abstract

Garlic oil is known to have medicinal effect on hypertension, heart desease, anemia and various infections. The active principles are reported to be allicin, diallil disulfide, allilpropyl disulfide, scorduun, selenium and germanium in addition to the presence of anticoagulant, anuhaemolytic and arulthrombotic agents. The methods applied for isolation and other conditions during the isolation affect the yield or the compositions of the oil, for instance with steam distillation the allicin will decompose whereas extraction at room temperature will yield oil with allicin as the main component. In the present study isolation was conducted by extraction with ethylacetate or ethanol and the oil obtained was tested for their antibacterial capacity. Tests against Staphylococcus aureus, Bacillus cereus and Escherichia coli indicated that the isolated oil were active. On the other hand, commercial garlic extract (KGE) and garlic oil capsule (GOC) gave negative test. This may have been due to either insufficient concentration. of the biologically active component present in the commercial drugs or different method of extraction process. investigation with thin layer chromatography (TLC) of the drugs On silica gel plate ustngn-hexane and ethyl acetate as eluents showed six components in the GOC and none in KGE whereas for the isolated oil 13 components were identified with iodine vapour. Although the oils indicated antibacterial activity, it is somehow less active compared with oxytetracycline which is used as reference.
ANTIBACTERIAL ACTIVITY OF FRACTIONATED SANDALWOOD OILS A. T. Karossi; H. Agustina; L. Sutedja
Jurnal Kimia Terapan Indonesia Vol 3, No 1 (1993)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2688.792 KB) | DOI: 10.14203/jkti.v3i1.299

Abstract

Sandalwood oil was prepared through water distillation of sandalwood (Sansalum album L) sawdust. The inhibitory activity of the oil was tested against Staphylococcus aureus and Bacillus cereus. This antibacterial active oil was further fractionated through column chromatography into five fractions. Larger antibacterial activity, expressed as inhibitory diameter ( ID ), was observed in the prepared sandalwood oil and its fractions compared to sandalwood oil originated from Kupang and sanialol from International Flavors and Fragrance ( IFF ). The inhibitory diameter of the isolated sandalwood oil against S. aureus and B. cereus were 8.75 and 8.20 mm respectively. While the IV of sandalwood oil from Kupang and santalol IFF against S aureus were 7.20 and 7.23 mm, and against B. cereus 6.62 and 7.35 mm respectively. The ID of the sandalwood oil fractions against S aureus ranged between 7.32 - 9.93 mm, and the largest inhibition was shown by fraction -2. Against Bicereus the IV ranged between 7.64 - 11.12 mm., and the largest inhibition was shown by fraction - 1. Suggested possible structures for sandalwood oil fractions were based on the infra red spectra of the oils and sandalwood oil components.
Co-Authors A. T. Karossi H. Agustina M. Hanafi