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Zalinar Udin
Pusat Penelitian Kimia-LiPI JI. Cisitu - Sangkuriang Bandung 40135
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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STUDI POTENSI EKSTRAK BRUCEA JAVANICA SEBAGAI BIOAKTIF ANTIKANKER PAYUDARA TERHADAP SEL T47D Rina Andriyani; Zalinar Udin
Jurnal Kimia Terapan Indonesia Vol 12, No 1 (2010)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4315.616 KB) | DOI: 10.14203/jkti.v12i1.145

Abstract

research. Buah makasar (Brucea javanica) known has anticancer activity.This research would bioassay the anticancer activity ofBrucea javanica extract toward T47D breast cancercell by in-vitro method, using SRB dyed. In order to study the mechanism, a dot blotting method was carried out to observe the interaction between the Brucea javanica extract with the chromosomal DNA molecule of T47D Cell Line. The interaction results were analyzed with High Performance Liquid Chromatography (HPLC) methods.The result of anticancer activity assay toward T47D cell showed that Brucea javanica extract has activity with IC50 2.69 g/mL, whereas, the interactionresult was analyzed with High Performance Liquid Chromatography (HPLC) methods, exhibited the reduction peaks with the retention time 2.26; 3.63 and 3.94 minutes. It was concluded that the bioactive activity ofBrucea javanica due to the presenceof these candidates.Keyword: Anticancer bioactivity, DNA ofT47D ceIl,
Co-Authors Rina Andriyani