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All Journal Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Pharmaceutical Education
Moh Adam Mustapa
Jurusan Farmasi
Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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Antimalarial activity and phitochemical analysis from Suruhan (Peperomia pellucida) extract Nurhayati Bialangi; Moh Adam Mustapa; Yuszda K Salimi; Ari Widiantoro; Boima Situmeang
Jurnal Pendidikan Kimia (JPKim) Vol 8, No 3 (2016): Desember
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.757 KB) | DOI: 10.24114/jpkim.v8i3.5817

Abstract

Abstract. Infectious and parasitic diseases is one of various disease that the most common. Based on data from the World Health Organization (WHO) in 2011, infectious and parasitic diseases become the third largest cause of death in the world. One of the plants that have potential as an antimalarial is suruhan (Peperomia pellucida). The purpose of this study is to test antimalarial activity against Plasmodium falciparum and analysis photochemistry consituen from extract suruhan. Antimalarial activity test using Desjardin method. Extraction was done by using maceration wuth methanol as a solvent and fractionation using partition methods. Results of phytochemical screening revealed the presence of alkaloids, flavonoid, steroid, saponins and triterpenoid test results antimalarial activity fraction of n-hexane, ethyl acetate and water show IC50 values are 12.80, 2.90 and 10.74 mg/ mL respectively.Keyword: Peperomia pellucida, suruhan, antimalarial
Uji Toksisitas Ekstrak Metanol Daun Kecubung (Datura metel L) Menggunakan Metode BSLT (Brine Shrimp Lethality Test) A. Mu’thi Andy Suryadi; Moh Adam Mustapa; Muhammad Taupik; Beby Bestari
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13272

Abstract

Amethyst plant (Datura metel L.) is often used by people as traditional medicine. This plant contains alkaloids, flavonoids, saponins, tannins, and steroids. Meanwhile, some of these compounds with certain levels can be cytotoxic. Toxicity test using the Brine Shrimp Lethality Test (BSLT) method is an initial screening to test a plant that has cytotoxic potential for the development of anticancer drugs. The purpose of this study was to determine the toxicity of the methanol extract of the leaves of Amethyst (Datura metel L.) to shrimp larvae (Artemia salina Leach) using the BSLT method. The test was carried out using several concentration variations, which are 10, 20, 40, 80, and 160 μg/Ml, and a control solution with 3 replications. Each concentration used 10 larvae, and observations were made for 24 hours on larval mortality. Thus, the findings found that the methanol extract of the amethyst leaf (Datura metel L) was potentially very toxic with an LC50 value of 46.1636 μg/mL.
Co-Authors A. Mu’thi Andy Suryadi Ari Widiantoro Beby Bestari Boima Ramses Situmeang Muhammad Taupik Nurhayati Bialangi Yuszda K Salimi