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Yoga I Kasjmir
Division of Rheumatology, Department of Internal Medicine, University of Indonesia School of Medicine/Cipto Mangunkusumo General Hospital, Jakarta
Medicine & Pharmacology

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Atherosclerosis prevalence and the correlation between atherosclerosis risk factors and carotid intima-media thickness in below 40-year-old women with systemic lupus erythematosus R M Sari; Yoga I Kasjmir; D Antono; S Setiati
Indonesian Journal of Rheumatology Vol. 2 No. 1 (2010): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.329 KB) | DOI: 10.37275/ijr.v2i2.33

Abstract

Objectives: To determine the prevalence of atherosclerosis in female systemic lupus erythematosus (SLE) patients aged below 40 years old and the factors correlated with carotid intima-media (CIM) thickening.Methods: A cross-sectional study was conducted on 80 female SLE respondents aged below 40 years old who were either in- or outpatient of Cipto Mangunkusumo General Hospital, Jakarta. History of disease and treatment was taken, and laboratory test and  ultrasonography of the carotid artery to evaluate CIM thickness were performed.Results: The prevalence of atherosclerosis was 40%, comprising of CIM thickening and/or presence of atherosclerotic plaque in the carotid artery. The median values of CIM thickness in the right common carotid artery, right carotid bulb, left common carotid artery, and left carotid bulb were 0.040 cm, 0.04535 cm, 0.0430 cm, and 0.047 cm, respectively. There was also a positive correlation reported of CIM thickness with increased age, the duration of SLE disease, and the duration of steroid treatment.Conclusions: We found a positive correlation of CIM thickness with age, the duration of SLE disease, and the duration of steroid treatment in female SLE patients aged below 40 years.
Knee function measured by timed up-and-go test and stair-climbing test after isometric exercise of quadriceps femoris muscles in female patients with knee osteoarthritis S C Widjanantie; A BM Tulaar; Yoga I Kasjmir; S B Prasetyo
Indonesian Journal of Rheumatology Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.219 KB) | DOI: 10.37275/ijr.v3i1.39

Abstract

Background: Osteoarthritis (OA), the most common form of joint disease, can result in long-term disability. Limitation of activity in OA patients may result in a decline in the strength of quadriceps femoris muscles and thus further reduce mobility. Isometric exercise has been known to increase muscle strength, decrease pain, and improve knee function.Objective: To evaluate knee function measured by timed up-and-go test (TUGT) and stair-climbing test (SCT) as well as muscle strength in the fourth and sixth week after isometric exercise of quadriceps femoris muscles and the correlation between these variables.Methods: Female patients with OA underwent isometric exercise of quadriceps femoris muscles 3 times a week for 6 weeks. Muscle strength (measured by tensiometer cable) and knee function (measured by TUGT and SCT) were evaluated before and at week 4and 6 of the exercise.Results: Thirty fi ve female patients were recruited in this study. The majority of the patients (45.7%) were between 60 to 65 years old. Obesity was found in 62.86% of the patients. At week 6, there was significant decrease in mean TUGT and SCT (by 39.0% and 45.6%, respectively; p<0.001), and signifi cant increase in mean right and left quadriceps muscles strength (by 47.9% and 36.7%, respectively; p<0.001). There was a weaknegative correlation (nonsignifi cant) of the increased strength of quadriceps muscles with the increase of knee function according to TUGT (right leg: r = -0.172, p = 0.323; left leg: -0.303, p = 0.077) and SCT (right leg: r = -0.031, p = 0.860); left leg: r = -0.058, p = 0.742).Conclusion: In female patients in this study, significant improvement was found in the strength of quadriceps muscles, TUGT, and SCT after 6 weeks of isometric exercise. There was no signifi cant correlation between muscle strength and knee function according to TUGT and SCT.
Correlation of interleukin-17 with disease activity and hand joint damage in patients with rheumatoid arthritis Jeffrey Arthur Ongkowijaya; Bambang Setiyohadi; Ida Ayu Ratih Wulansari Manuaba; Yoga I Kasjmir
Indonesian Journal of Rheumatology Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.456 KB) | DOI: 10.37275/ijr.v2i3.80

Abstract

Background: Rheumatoid arthritis (RA) is a disease involving various types of cytokines. One of them is interleukin-17 (IL-17), which is known to have a pleiotropic effect on various of cells and is thought to be a cytokine effector contributing to the pathogeniccondition in RA.Methods: The study was conducted on 46 RA patients at rheumatology clinic at the Cipto Mangunkusumo General Hospital who were diagnosed based on the 1987 American College of Rheumatology criteria. Sample selection was done using consecutive sampling. Tests on patients were conducted to collect data needed to obtain the scores for 28-joint Disease Activity Score (DAS28), global health visual analogue scale, swollen joint count, tender joint count, sedimentation rate, Sharp score (radiograph of both hands), and the IL-17 level.The correlation between IL-17 level and DAS28 was  calculated using the Pearson’s correlation test while the correlation between IL-17 level and Sharp score was calculated using the Spearman’s test.Results: The majority of patients (87%) were women. The largest percentage was in the 51- to 60-year-old group (39.1%). Most patients (43.1%) had moderate disease activity. There were 27 patients (58.69%) with positive rheumatoid factor. The mean IL-17 level was17.28 pg/mL with a standard deviation of 11.43 pg/mL. There was no correlation of IL-17 level with disease activity (p = 0.446, r = 0.021) and Sharp score (p = 0.304, r = 0.077) in subjects of this study.Conclusion: There was no signifi cant correlation of IL-17 with disease activity and joint damage.
Co-Authors A BM Tulaar Bambang Setiyohadi D Antono Jeffrey Arthur Ongkowijaya R M Sari S B Prasetyo S C Widjanantie S Setiati