Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Indonesian Journal of Rheumatology
N Sukmana
Division of Allergy and Immunology, Department of Internal Medicine, University of Indonesia School of Medicine/Cipto Mangunkusumo General Hospital, Jakarta
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Prevalence of anti–C-reactive protein autoantibody and its correlation with disease activity in systemic lupus erythematosus patients at Cipto Mangunkusumo General Hospital Lusiani Lusiani; Bambang Setiyohadi; N Sukmana; M Abdullah
Indonesian Journal of Rheumatology Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.42 KB) | DOI: 10.37275/ijr.v2i3.81

Abstract

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with various underlying mechanisms characterized by autoantibody overproduction. It has been known that mortality and morbidity of SLE was higher in Asian patients compared with white patients. Several studies had showed that C-reactive protein (CRP) has the ability to suspend the progression of SLE through regulatory and clearance pathway, and low level of CRP and high level of anti-CRP antibody has been detected in SLE patients. A question raise whether mortality and morbidity in Asian SLE patients are associated with anti-CRP antibody.Objective: To study the prevalence of anti-CRP antibody and its relationship with disease activity in SLE patients at Cipto Mangunkusumo General Hospital,Jakarta.Methods: This is a cross-sectional study conducted at Cipto Mangunkusumo General Hospital from December 2009 until May 2010. Subjects were SLE patients whowere diagnosed based on the 1982 American College of Rheumatology criteria. Disease activity was measured using the Mexican SLE Disease Activity Index scoringsystem. Anti-CRP antibody assay was performed using the Western blot analysis. Correlation between the presence of anti-CRP antibody and disease activitywas evaluated using the T-test and multivariate logistic regression analysis.Result: Forty SLE patients with a mean age of 31.65 (SD 8.84) were enrolled in the study, 33 of which (82.5%) had positive autoantibody to CRP pentamer. The anti-CRP antibody was signifi cantly correlated (p = 0.024) with disease activity. Conclusions: There was a relatively large proportion of patients with positive anti-CRP antibody among SLE patients in Cipto Mangunkusumo General Hospital. Therewas also a signifi cant correlation between anti-CRP antibody and the disease activity.
Invasive aspergillosis in a systemic lupus erythematosus patient Bambang Setiyohadi; M S Azizi; Ika Wulan Yuliani; N Sukmana; Suhendro Suhendro; M Simadibrata; C Matin Rumende; A S Sulaiman; R Wahyuningsih; Lisnawati Lisnawati; M A Yudharto; N Anggraini; F Oktaviana; R Sandra
Indonesian Journal of Rheumatology Vol. 2 No. 2 (2010): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.027 KB) | DOI: 10.37275/ijr.v2i3.82

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with a broad clinicalmanifestation characterized by production of antibodies against cellular nuclear components. The prevalence of SLE among many countries is variable, ranging from 2.9 to 400 per 100,000. In Cipto Mangunkusumo General Hospital, the incidence of SLE between 1990 and 1998 is 37.3 per 10,000 hospitalization.1 Patients with autoimmune disease have at least twofold risk of acquiring infections compared with healthy individuals. This may be due to the immunosuppresant therapy but could also caused by the primary immune dysregulation that was the basis for the pathogenesis of their disease, or other autoimmune disease manifestations such as lymphopenia.2 Infection is the main factor increasing the mortality and morbidity of SLE patients. A study in New York conducted between 1966 and 1976 involving 223 SLE patients reported 150 cases of infection, of which 23 were opportunistic infection: 12 were candidiasis while 11 others were deep fungal infection. The use of corticosteroids in SLE is the main factor that predispose patients to infection, particularly fungal infection.3 Aspergillosis is the term used to denote all disease caused by any one of the pathogenic and allergenic species of Aspergillus. The annual incidence of aspergillosis in the United States is reported to be 1–2 per 100,000.4 Aspergillus fumigatus is the cause of most cases of invasive aspergillosis, almost all cases of chronic aspergillosis, and most allergic syndromes. The mortality rate of invasive aspergillosis is 50% when properly diagnosed and treated; otherwise it could be as high as 100%
Co-Authors A S Sulaiman Bambang Setiyohadi C Matin Rumende F Oktaviana Ika Wulan Yuliani Lisnawati Lisnawati Lusiani Lusiani M A Yudharto M Abdullah M S Azizi M Simadibrata N Anggraini R Sandra R Wahyuningsih Suhendro Suhendro