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All Journal Majalah Farmaseutik
Wahyu Irawan
Fakultas Farmasi, Universitas Gadjah Mada
Medicine & Pharmacology

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OPTIMIZING FORMULA OF FAST DISINTEGRATING TABLET NATRIUM DICLOFENAC β-CYCLODEXTRIN INCLUSION COMPLEX WITH CROSPOVIDONE AS THE SUPERDISINTEGRANT AND MICROCRYSTALLINE CELLULOSE PH 102 AS THE FILLER BINDER Wahyu Irawan; T.N. Saifullah Sulaiman
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (518.474 KB) | DOI: 10.22146/farmaseutik.v12i2.26453

Abstract

Natrium diclofenac (Na-DCF) is one of non-steroidal anti-inflammatory drug (NSAID) that have a bitter taste. The inclusion complex of NaDCF with β-cyclodextrin (BSD) can be made to mask the unpleasant taste. The inclusion complex of natrium diclofenac-β-cyclodextrin (NaDCFBSD) was prepared by spray drying method in 1:1 molar ratio. NaDCF, BSD, and NaDCF-BSD inclution complex was characterized by Fourier Transform Infrared Spectroscopy (FTIR). NaDCF-BSD complex was formulated into Fast Disintegrating Tablet (FDT) by optimizing crospovidone as superdisintegrant and microcrystalline cellulose (MCC) PH 102 as filler binder. FDTs were made by direct compression method. A respond test of taste was conducted on the FDT of optimum formula. The optimum physical properties of FDTs were produced by formulating 5,79% crospovidone and 39,21% MCC PH 102. The respond test of taste results showed that FDT with NaDCF in inclution complex have a better taste than FDT with NaDCF without inclusion complex.
Co-Authors T.N. Saifullah Sulaiman