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All Journal Majalah Farmaseutik
Cahyarani Intan Ramadhani
Department of Pharmacy, Mathematics and Natural Science Faculty, Universitas Sebelas Maret, Surakarta
Medicine & Pharmacology

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Formulation of Anti-Acne Gel of Moringa oleifera, L. Ethanolic Extract and Antibacterial Test on Staphylococcus epidermidis Dian Eka Ermawati; Cahyarani Intan Ramadhani
Majalah Farmaseutik Vol 16, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3929.634 KB) | DOI: 10.22146/farmaseutik.v16i2.50319

Abstract

Moringa oleifera L. leaves contain flavonoid, alkaloid, and phenolic compounds which have antibacterial activity. Staphylococcus epidermidis is one of the bacteria that causes acne. The purpose of this study is to compare bacteriostatic ability of the extracts and gel for S. epidermidis bacteria and to get gel formula that can fulfills the physical properties of a good gel. Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 was used as the polymer. Extract was added with variation concentrations of 5, 10, and 15%. Physical evaluation of gel was organoleptic, homogeneity, pH, viscosity, adhesion, and spread tests for 4 weeks. In vitro bacteriostatic activity test with 1% clindamycin gel as positive control and polymer gel as negative control. The result showed that variations concentrations of ethanolic extract of Moringa leaves affected the physical properties of gel including viscosity, pH, adhesion and spreadability. Bacteriostatic activity test of ethanolic extract of Moringa leaf was classified as strong activity, while 15% Moringa leaf ethanol extract gel was classified as moderate activity with average diameter was 9.14 mm
Co-Authors ERMAWATI, DIAN EKA