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All Journal Indonesian Journal of Chemistry
Zulfa Khoirunni’mah
Program Study Pharmacy-Faculty of Medicine and Health Sciences, Syarif Hidayatullah State Islamic University (UIN) Jakarta
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Synthesis Methyl Nitrophenyl Acrylate and Cytotoxic Activity Test against P388 Leukemia Cells Teni Ernawati; Zulfa Khoirunni’mah
Indonesian Journal of Chemistry Vol 15, No 1 (2015)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.357 KB) | DOI: 10.22146/ijc.21226

Abstract

Synthesis of methyl nitrophenyl acrylate via modification of methyl trans-cinnamate had been done to improve its biological activity. The reaction of methyl trans-cinnamate with nitrating agent gave methyl 3-(2-nitrophenyl)acrylate and methyl 3-(4-nitrophenyl)acrylate with an ortho/para ratio of 1:8. Its structure was confirmed with 1H-NMR, 13C-NMR, FTIR, GC-MS. Biological activity of methyl 3-(4-nitrophenyl)acrylate and methyl 3-(2-nitrophenyl)acrylate assays was performed on Cancer cells against P388 Murine Leukemia with IC50= 7.98 μg/mL, IC50 = 27.78 μg/mL.
Co-Authors Teni Ernawati