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I Ketut Triyono
High School 96 Jakarta, Jl. Jati Raya No. 40, Cengkareng Barat, Jakarta Barat, DKI Jakarta 11840
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Cytotoxic Isobractatin (Prenylated Xanthone) Epimer Mixture of Garcinia eugenifolia Sri Hartati; I Ketut Triyono; Sri Handayani
Indonesian Journal of Chemistry Vol 14, No 3 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.153 KB) | DOI: 10.22146/ijc.21239

Abstract

In search of bioactive anti-cancer compounds from natural products has been found isobractatin from n-hexane extract of Garcinia eugenifolia. Isolation was done through the stages of maceration and column chromatography. Elucidation of the structure was analyzed by spectroscopy of UV-Vis, FTIR, LC-MS, NMR proton and carbon one and two dimension data. The results found three compounds isolated from G. eugenifolia. The three compounds were stigmasterol, prenylated xanthone isobractatin and its epimer (in a mixture). The mixture of isobractatin and its epimer showed cytotoxic activity against breast cancer cell line T47D with IC50 = 17 µg/mL.
Co-Authors Sri Handayani Sri Hartati