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All Journal Indonesian Journal of Chemistry
Syafruddin Syafruddin
Eijkman Institute for Molecular Biology, Jl. Diponegoro No. 69, Jakarta 10430
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Antiplasmodial Evaluation of One Compound from Calophyllum flavoranulum Jamilah Abbas; Syafruddin Syafruddin
Indonesian Journal of Chemistry Vol 14, No 2 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.477 KB) | DOI: 10.22146/ijc.21257

Abstract

Calophyllum flavoranulum (Clusiaceae family) is a big tree and medical plants from the tropical rain forest of the Indonesian continent. The organic extracts from stem bark yielded phenyl coumarin. The structure was elucidated with the aid of spectroscopic technique. Antiplasmodial activities of isolated compound was tested in vivo against Plasmodium berghei parasite and showed the best antiplasmodial activity. New flavoranulum coumarin compound showed activity against P. berghei parasite with inhibition growth 0, 31.33, 40, 30.67, 46 and 34% at dosage 1.1x10-10, 1.1x10-9, 1.1x10-8, 1.1x10-7, 1.1x10-6, and 1.1x10-5 mg/mL, respectively. Flavoranulum coumarin very active as antiplasmodial, and at 3 and 4 day incubation all of parasite were died.
Co-Authors Jamilah Abbas