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Mustofa Mustofa
Pharmacology Division, Faculty of Medicine, Universitas Gadjah Mada, Jl. Farmaco Yogyakarta
Chemical Engineering, Chemistry & Bioengineering Chemistry

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SYNTHESIS 7-O-CARBOXYMETHYL-3’,4’-DIMETHOXYISOFLAVONE Andi Hairil Alimuddin; Sabirin Matsjeh; Chairil Anwar; Mustofa Mustofa
Indonesian Journal of Chemistry Vol 12, No 3 (2012)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.586 KB) | DOI: 10.22146/ijc.21337

Abstract

Synthesis of 7-O-carboxymethyl-3',4'-dimethoxyisoflavone from 7-hydroxy-3',4'-dimethoxyisoflavone derived from eugenol had been done. 7-hydroxy-3',4'-dimethoxyisoflavone was first converted into 7-O-ethoxycarbonylmethyl-3',4'-dimethoxyisoflavone via substitution of hydroxyl group at 7-O position by ethyl-2 chloro acetate through bimolecular nucleophilic substitution reaction (SN2). Hydrolysis of ester group of 7-O-ethoxycarbonylmethyl-3',4'-dimethoxyisoflavone using KOH produce 7-O-carboxymethyl-3',4'-dimethoxyisoflavone in 93.4% yield as a white solid with melting point of 155-159 °C.
Co-Authors Andi Hairil Alimuddin Chairil Anwar Sabirin Matsjeh