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Suharso Suharso
Department of Chemistry, University of Lampung, Bandar Lampung 35145
Chemical Engineering, Chemistry & Bioengineering Chemistry

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IN VITRO ACTIVITY AND COMPARATIVE STUDIES OF SOME ORGANOTIN(IV) BENZOATE DERIVATIVES AGAINST LEUKEMIA CANCER CELL, L-1210 Sutopo Hadi; Mita Rilyanti; Suharso Suharso
Indonesian Journal of Chemistry Vol 12, No 2 (2012)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.578 KB) | DOI: 10.22146/ijc.21359

Abstract

A series of dibutyl-, diphenyl- and triphenyltin(IV) benzoate derivatives has been prepared. The products were obtained by reacting the dibutyltin(IV) dichloride, diphenyltin(IV) dichloride and triphenyltin(IV) chloride respectively via the dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with benzoate acid and its derivative. The targeted compounds have been tested with anticancer activity against leukemia cancer cell, L-1210. The compounds synthesized were well characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies as well as based on the microanalytical data. The results showed that triphenyltin(IV) benzoate and its derivative prepared exhibit higher anticancer activity than those of dibutyltin(IV) and diphenyltin(IV) analogous.
Co-Authors Mita Rilyanti Sutopo Hadi