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All Journal Indonesian Journal of Chemistry
Sunarso Sunarso
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
Chemical Engineering, Chemistry & Bioengineering Chemistry

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EFFECT OF CROSSLINKING TO THE MECHANICAL PROPERTY OF APATITE GELATIN HYBRID FOR BONE SUBSTITUTION PURPOSES Sunarso Sunarso; Sutarno Sutarno; Kanji Tsuru; Ika Dewi Ana; Kunio Ishikawa
Indonesian Journal of Chemistry Vol 11, No 3 (2011)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.517 KB) | DOI: 10.22146/ijc.21391

Abstract

The clinical success of current generation of synthetic bone substitute relies on bio-inspired design which has a performance level close to that of natural one. In this context, biomedical approaches are considered very important to result bio-functional hybrid for bone substitution purposes. In this study, effect of cross-linking to the mechanical properties of apatite gelatin hybrid has been investigated. Cross-linking was employed by 1-ethyl-3-3-dimethylaminopropyl carbodiimide (EDC) agent. The EDC agent creates a peptide bond between gelatin molecules inside the hybrid to the cross-linked structure. Cross-linked structure of gelatin increases physical property of the hybrid since it can hold the outer forces longer than that of without cross-linking.
Co-Authors Ika Dewi Ana Kanji Tsuru Kunio Ishikawa Sutarno Sutarno