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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Chemistry
Zullies Ikawati
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Medicine & Pharmacology Public Health

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DOCKING OF 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYL-PYRAZOLE TO CYCLOOXYGENASE-2 USING PLANTS Stefanus Layli Prasojo; Fajar Agung Dwi Hartanto; Nunung Yuniarti; Zullies Ikawati; Enade Perdana Istyastono
Indonesian Journal of Chemistry Vol 10, No 3 (2010)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.937 KB) | DOI: 10.22146/ijc.21441

Abstract

The docking protocols to virtually screen selective cyclooxygenase-2 (COX-2) ligands using PLANTS docking software were developed and validated. The crystal structure of 1-phenylsulfonamide-3-trifluoromethyl-5-parabromophenyl-pyrazole (S58) binds to cyclooxygenase-2 (COX-2) was used as the reference structure. The developed protocols could predict the binding pose of S58 to COX-2 accurately (RMSD is 1.2 Ǻ).
Renal Safety of Long-Term Antihypertensive Therapy: A Systematic Review Thendi Abdul Arief; Yohanna Lawanda da Costa; Niky Budiarti; Luthfiah Pertiwi; Agung Endro Nugroho; Zullies Ikawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.108256

Abstract

Background: Managing hypertension, a major risk factor for chronic kidney disease (CKD), requires long-term antihypertensive medication. However, clinical judgment and medication adherence are impacted by ongoing worries about its renal safety.Objectives: This study aimed to systematically evaluate and compare the renal safety profiles of antihypertensive drug classes during long-term use (>6 months) in hypertensive patients.Methods: Following the PRISMA 2020 principles, a systematic review was carried out. A thorough search of PubMed and ScienceDirect from 2015 to April 2025 was conducted ("ACEi OR ARB OR CCB OR Beta Blocker OR Diuretic AND Hypertension AND long-term use AND Renal Function"). A narrative synthesis was carried out in compliance with the Synthesis Without Meta-Analysis (SWiM) guideline due to clinical and methodological heterogeneity.Results: A total of 7214 studies were retrieved and reviewed. Only five papers were chosen after additional analysis. In comparison to CCBs in advanced chronic kidney disease (CKD), diuretics in combination with renin-angiotensin system inhibitors (RASi) were linked to a decreased incidence of significant adverse renal events (weighted HR 0.87, 95% CI 0.77-0.97). Despite a higher frequency of reversible eGFR drop and hyperkalemia, continuous ACEi/ARB treatment before dialysis initiation significantly decreased post-dialysis mortality (aHR 0.87, 95% CI 0.83-0.92). Compared to amlodipine, ACEi alone reduced eGFR and raised serum levels of potassium and creatinine for at least a year. In patients with resistant hypertension and baseline eGFR ≥30 mL/min/1.73 m², spironolactone successfully reduced blood pressure; however, initial elevations in serum creatinine and potassium needed to be monitored. Since blood pressure was well controlled, there was no discernible difference between ARBs and CCBs regarding the risk for end-stage kidney disease (HR 0.28; CI 0.14-0.58).Conclusion: Combining RASi with a diuretic provides superior renal protection for CKD patients compared to CCB. Post-dialysis mortality is also decreased by long-term ACEi/ARB usage. Under careful supervision, spirolactone is both safe and effective. Thus, regular use of ACEi/ARB and diuretic-RASi combination therapy is a safe and effective long-term method for maintaining renal function in hypertension.
Agreement Between WHO-UMC Causality scale and the Naranjo Algorithm for Causality Assessment of Adverse Drug Reactions at Health Care Services in Yogyakarta Hafifah Ernawati; Zullies Ikawati; Ika Puspita Sari; Siti Asfijah Abdoellah; Fivy Kurniawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.110131

Abstract

Background: The WHO-UMC system and Naranjo algorithm are the most widely used tools for evaluating the causality of adverse drug reactions (ADRs) reports. Despite their wide application, a direct comparison of these methods in the context of Indonesia's ADR reporting has not yet been explored.Objectives: This study aimed to compare the agreement of causality assessment and correlation between the two methods of the WHO-UMC system and the Naranjo algorithm.Methods: In this study, 255 suspected adverse drug reactions (ADR) from 169 safety reports were analyzed in 2023, reported at healthcare services in Yogyakarta. Two independent raters performed causality assessments using the WHO-UMC criteria and Naranjo algorithm. The raters were blinded to each other's assessment results, and the assessments were conducted at different locations and times. The agreement between the two ADR causality scales was assessed using Cohen's kappa. Spearman’s correlation was also used to find the correlation between the two scales.Results: ADRs were most frequently reported by pharmacists, with the most commonly suspected drug class being antibiotics. The agreement between the two methods for all ADR cases was a Cohen's Kappa coefficient value of 0.384, indicating minimal agreement. The correlation between the two methods was 0.501, indicating a moderately positive relationship.Conclusion: A minimal moderate level of agreement was observed between the WHO-UMC and Naranjo scales. The level of agreement for serious ADR cases was classified as weak, whereas for non-serious ADR cases, it was classified as minimal. The correlation between the two methods was moderately positive.
Co-Authors Agung Endro Nugroho Enade Perdana Istyastono Ernawati, Hafifah Fajar Agung Dwi Hartanto Fivy Kurniawati Ika Puspita Sari Luthfiah Pertiwi Niky Budiarti Nunung Yuniarti Siti Asfijah Abdoellah Stefanus Layli Prasojo Thendi Abdul Arief Yohanna Lawanda da Costa