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Elida Purba
Department of Chemical Engineering, Faculty of Engineering, Lampung University, Bandar Lampung 35145
Chemical Engineering, Chemistry & Bioengineering Chemistry

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DETERMINATION OF REACTION KINETICS USING ONLINE X-RAY DIFFRACTION Elida Purba
Indonesian Journal of Chemistry Vol 8, No 3 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1884.777 KB) | DOI: 10.22146/ijc.21588

Abstract

X-ray diffraction (XRD) is a powerful technique for the study of polymorphism and polymorphic phase transformations. Monitoring of phase transformation directly has been very limited to-date. The XRD system used in this study was used to determine the rate of transformation of pure glutamic acid a form to b form in a solution mediated phase. On every run starting from the pure a form, the transformation process was monitored continuously at fixed temperature, and separate experiments were performed as a function of temperature. The operating temperature was varied from 36 to 57 °C with 10% w/w solid concentration. Data were taken every 200 seconds until the transformation was completed. This paper is concerned with a study of the transformation of the alpha (a) form of L-glutamic acid (L-GA) to the beta (b) form in order to determine the kinetic reaction. The rate constant (k), activation energy (Ea) and pre-exponential factor (A) were obtained. Sensitivity tests were also carried out to examine minimum detection limit when both a and b present in the mixture. In addition, effect of particle size on XRD patterns was also determined. The results show that XRD gives useful information to observe polymorphism for pharmaceutical industry.
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