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All Journal IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Indonesian Journal of Chemistry
Hermansyah Hermansyah
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science

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Synthesis and Characterization of Chitosan Linked by Methylene Bridge and Schiff Base of 4,4-Diaminodiphenyl Ether-Vanillin Ahmad Fatoni; Poedji Loekitowati Hariani; Hermansyah Hermansyah; Aldes Lesbani
Indonesian Journal of Chemistry Vol 18, No 1 (2018)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.923 KB) | DOI: 10.22146/ijc.25866

Abstract

The synthesis chitosan-methylene bridge-Schiff base of 4,4-diaminodiphenyl ether-vanillin using casting method has been done. The aims of this research were modification chitosan with Schiff base of 4,4-diaminodiphenyl ether-vanillin, formaldehyde and its characterization using FTIR spectroscopy, SEM analysis, 1H-NMR and X-Ray Diffraction analysis. The first step was a synthesis of modified chitosan between chitosan and Schiff base of 4,4-diaminodiphenyl ether-vanillin. The second step was chitosan modified Schiff base of 4,4-diaminodiphenyl ether-vanillin then reacted with formaldehyde through casting method. The result showed that chitosan can be modified with Schiff base of 4,4-diaminodiphenyl ether-vanillin and formaldehyde and this modified chitosan can be linked by methylene bridge (-NH-CH2-NH-) and had azomethine group (-C=N-). The functional group of –C=N in modified chitosan before and after adding formaldehyde appeared at a constant wavenumber of 1597 cm-1. The functional group C-N in methylene bridge detected at 1388 and 1496 cm-1. The chitosan-Schiff base of 4,4-diaminodiphenyl ether-vanillin and Chitosan-methylene bridge-Schiff base of 4,4-diaminodiphenyl ether-vanillin had index crystalline (%)16.04 and 25.76, respectively. The chemical sift of signal proton azomethine group (-C=N-) in modified chitosan detected at 8.44–8.48 and 9.77 ppm. Proton from methylene bridge in modified chitosan appeared at 4.97–4.99 and 3.75 ppm. Surface morphology chitosan-methylene bridge-Schiff base of 4,4-diaminodiphenylether-vanillin had dense surfaces, mostly uniform and regular in shape.
Coumarin Derivative from the Unripe Fruit of Mengkudu (Morinda citrifolia Linn) and Cytotoxic Activity Ferlinahayati Ferlinahayati; Sarifatun Nisa; Hermansyah Hermansyah; Dasril Basir
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 8, No 2 (2023): June 2023
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v8.i2.70

Abstract

A coumarin derivative namely scopoletin (7-hydroxy-6-methoxychromen-2-one) had been isolated from the methanol extract of unripe noni fruits (Morinda citrifolia Linn.). The extraction was conducted by maceration, continuing with separation and purification using several techniques of chromatography. The yellowish isolated compound showed a melting point at 200 – 202 °C. The compound structure was analyzed based on spectral data 1H-NMR, 13C-NMR, and NOE 1D. The inhibition of methanol extract of noni fruits and scopoletin against murine leukemia P388 cells using MTT assay showed IC50 were > 100 μg/mL and 65.69 μg/mL respectively. These showed that scopoletin was more cytotoxic than methanol extract but weaker than artonin E as a positive control IC50 0.48 μg/mL)
Co-Authors Ahmad Fatoni Aldes Lesbani Dasril Basir Ferlinahayati Ferlinahayati Poedji Loekitowati Hariani Sarifatun Nisa