Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Indonesian Journal of Chemistry
Dian Ayu Utami
Jenderal Achmad Yani University, Jl. Terusan Jenderal Sudirman Cimahi, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Synthesis of 131I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals Maula Eka Sriyani; Dian Ayu Utami; Mega Susilo Dwike; Eva Maria Widyasari; Muharram Marzuki; Rizky Juwita Sugiharti; Witri Nuraeni
Indonesian Journal of Chemistry Vol 19, No 4 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.666 KB) | DOI: 10.22146/ijc.34512

Abstract

Quercetin is one of the flavonoid groups with antioxidant activity. The objective of this study was to achieve the labeled compound of 131I-quercetin as a radiotracer for diagnosis and cancer therapy with high labeling efficiency and radiochemical purity. The labeling procedure was conducted by the oxidation reaction using chloramine-T. The effect of pH, reaction time, amount of oxidizing agent and ligand were evaluated in this research. Quercetin was successfully labeled with iodine-131 at pH 11 at room temperature for 10 min mixed in 1000 rpm with the amount of quercetin and chloramine-T is 0.4 and 0.3 mg, respectively. The results demonstrated that the ratio of quercetin/Na131I was 2 × 105. The 131I-quercetin labeling efficiency was 92.03 ± 2.20%, and radiochemical purity of 131I-quercetin was 99.34 ± 0.58%. The results showed that 131I-quercetin could be a radiotracer candidate for diagnosis and cancer therapy.
Co-Authors Eva Maria Widyasari Maula Eka Sriyani Mega Susilo Dwike Muharram Marzuki Rizky Juwita Sugiharti Witri Nuraeni