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Anis Low Muhammad Low
Atta-ur-Rahman Institute (AURINS), Universiti Teknologi MARA, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia
Chemical Engineering, Chemistry & Bioengineering Chemistry

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New Access to Pyrano[2,3-c]pyrazole-3-carboxylates via Domino Four-Component Reaction and Their Antimicrobial Activity Muhammad Siddiq Maarop; Fatin Nur Ain Abdul Rashid; Mohd Fazli Mohammat; Zurina Shaameri; Saiful Azmi Johari; Mazurah Mohamed Isa; Anis Low Muhammad Low
Indonesian Journal of Chemistry Vol 20, No 1 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.97 KB) | DOI: 10.22146/ijc.39566

Abstract

A library of some novel classes of pyrano[2,3-c]pyrazole-3-carboxylates was synthesized by employing uncatalyzed domino four-component reaction using diethyloxaloacetate, hydrazine hydrate, aldehydes and malononitrile in refluxing of ethanol-acetic acid solvent systems. Series of domino reactions involving of pyrazolone formation, Michael addition, and Thorpe-Ziegler cyclization reaction managed to produce the cyclized products from moderate to excellent yield. This protocol provides a reliable, general and salient procedure for the title compound using a one-pot approach. Preliminary biological screening unveiled limited potentials of this class of compounds for antimicrobial lead compound due to its limited solubility properties.
Co-Authors Fatin Nur Ain Abdul Rashid Mazurah Mohamed Isa Mohd Fazli Mohammat Muhammad Siddiq Maarop Saiful Azmi Johari Zurina Shaameri